SRYA_DROPS
ID SRYA_DROPS Reviewed; 551 AA.
AC Q07964; Q29C75;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Serendipity locus protein alpha;
GN Name=Sry-alpha; Synonyms=Sry-a; ORFNames=GA14740;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND DEVELOPMENTAL STAGE.
RX PubMed=8287797; DOI=10.1242/dev.119.2.471;
RA Ibnsouda S., Schweisguth F., de Billy G., Vincent A.;
RT "Relationship between expression of serendipity alpha and cellularisation
RT of the Drosophila embryo as revealed by interspecific transformation.";
RL Development 119:471-483(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required for the cellularization of the syncytial blastoderm
CC embryo. Involved in the localization of the actin filaments just prior
CC to and during plasma membrane invagination. Sry-alpha together with
CC nullo and bnk may provide auxiliary functions, by acting both to
CC stabilize a large and dynamic microfilament structure and regulate its
CC functions (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Note=Inner membrane-associated and cytoplasmic.
CC Colocalizes with the structural transitions in the microfilament
CC network during cellularization (By similarity). {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Blastoderm. {ECO:0000269|PubMed:8287797}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL26772.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; L19536; AAA17045.1; -; Unassigned_DNA.
DR EMBL; CM000070; EAL26772.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001357638.1; XM_001357601.4.
DR AlphaFoldDB; Q07964; -.
DR SMR; Q07964; -.
DR STRING; 7237.FBpp0283105; -.
DR EnsemblMetazoa; FBtr0284667; FBpp0283105; FBgn0243553.
DR GeneID; 4800250; -.
DR KEGG; dpo:Dpse_GA14740; -.
DR eggNOG; ENOG502SBC0; Eukaryota.
DR HOGENOM; CLU_030377_0_0_1; -.
DR InParanoid; Q07964; -.
DR OMA; ETIYLCF; -.
DR PhylomeDB; Q07964; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0243553; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0032154; C:cleavage furrow; IEA:EnsemblMetazoa.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0007015; P:actin filament organization; IEA:EnsemblMetazoa.
DR GO; GO:0007349; P:cellularization; IEA:EnsemblMetazoa.
DR InterPro; IPR008837; Serendipity_A.
DR Pfam; PF05482; Serendipity_A; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Developmental protein; Membrane;
KW Reference proteome.
FT CHAIN 1..551
FT /note="Serendipity locus protein alpha"
FT /id="PRO_0000072198"
FT CONFLICT 53..56
FT /note="RWGA -> DGG (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 88
FT /note="I -> V (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="E -> G (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="N -> K (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="S -> L (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="D -> G (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="H -> R (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 467..468
FT /note="KL -> NV (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 490
FT /note="Missing (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
FT CONFLICT 510
FT /note="Y -> F (in Ref. 1; AAA17045)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 551 AA; 61840 MW; 547DFDAC9DEDDACB CRC64;
MESLLRQLSI CNELIAQGPA CPVGNIAWLN EFCATFLDFA SELKAHLPEI APRWGAPEGG
NNIEVETIFL CLTQVVTCIT QLERTINIES KFGHETTPMT RLHFLDRIDW CVRRIYVSLS
QLDLHQESGA ADNLEDHTFV ELMDLALDHL EAFMEGLGNT TSNFLYIEEE NDTNDACQLG
SIINHIVRHA LAFANVALEA DKKALSELCE TLLSECTTFL EGSAELNPGH RKLEALSLER
ALYGLETFLN EALLHSIFAS LVELENTPIN RLRHALQEQE SESGLTEKLV SDFDTNMDRI
QQIGVLAIAF SQDVKTKTIV RSCLASLESL DACIVPALQS SALHHADILE HHFNDEMLIF
RNLIHDIIDS RSLVNNYLDM LAESLHIHIA GKSVPREYLL IVQMGSVLAE HFRLPVNYSA
LSDDGKRVHK DLILILRECL AAVSLATPVD PKRIVKRLKI LYSVLAKLRD VIDKNVHDSV
FNLSSRRQIT NATRTLLRSC KSKSKRQRSY VKQSQDSVVP DPHNYTSSIA NSISNDGDLI
SFQLTEILRI N
