ID   SRYA_DROSU              Reviewed;         543 AA.
AC   Q07965;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Serendipity locus protein alpha;
GN   Name=Sry-alpha; Synonyms=Sry-a;
OS   Drosophila subobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7241;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8287797; DOI=10.1242/dev.119.2.471;
RA   Ibnsouda S., Schweisguth F., de Billy G., Vincent A.;
RT   "Relationship between expression of serendipity alpha and cellularisation
RT   of the Drosophila embryo as revealed by interspecific transformation.";
RL   Development 119:471-483(1993).
CC   -!- FUNCTION: Required for the cellularization of the syncytial blastoderm
CC       embryo. Involved in the localization of the actin filaments just prior
CC       to and during plasma membrane invagination. Sry-alpha together with
CC       nullo and bnk may provide auxiliary functions, by acting both to
CC       stabilize a large and dynamic microfilament structure and regulate its
CC       functions (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Inner membrane-associated and cytoplasmic.
CC       Colocalizes with the structural transitions in the microfilament
CC       network during cellularization (By similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Blastoderm.
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DR   EMBL; L19535; AAA17044.1; -; Unassigned_DNA.
DR   AlphaFoldDB; Q07965; -.
DR   SMR; Q07965; -.
DR   FlyBase; FBgn0012949; Dsub\Sry-alpha.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007349; P:cellularization; IEA:InterPro.
DR   InterPro; IPR008837; Serendipity_A.
DR   Pfam; PF05482; Serendipity_A; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Developmental protein; Membrane.
FT   CHAIN           1..543
FT                   /note="Serendipity locus protein alpha"
FT                   /id="PRO_0000072199"
SQ   SEQUENCE   543 AA;  61451 MW;  07006B594692C838 CRC64;
     MESLLRQLSI CNELIAQGSC TAGHIDWLND FCATFLDFAS ELKAHLPEVA PRWPAEGGTN
     IDVETIFLCL TQVVTCITQL ERTINIEGAS ARATPMTRLH FLDRIDWCVR RIIFCLSQLH
     LQRANDQSNS LEDHTFVELM DLALDHLEAF METLANTTPT NLLCIVEENE LQLGSIVNHI
     VRHALAFANV ALEADKKALS ELCETLLSEC ATFLEDSGEL NPGHRKLEGL SLERALYGLE
     TYLNEALLHL IFACIVELEN TPISKLRHAP DSEFTEQLVL DFDTNMDRIQ QIGVLAIAFS
     QDIKTKTIVR SCLASLESLD ACIVPALQSS ALHPHHADIL EHHFNEEILI FRNLIHEIID
     SRSLINNYLD MLAESIHLAV KRPPRDHLLI VQMGSVLEEH FRLPVNYSEL SQLDGKRLHT
     DFMLILSECL AVVSSPLGEP KRIVKRLKIL YSVLAKLRHA IDRNKYVHED SSASVPNVSS
     RRQFTNATRT LLRMKSKSKR QRSFVRQRRD CLVPNPQNCS ISNSISHQGD LISFQLTEIL
     RIN