ID   SRYA_DROVI              Reviewed;         537 AA.
AC   O77201;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Serendipity locus protein alpha;
GN   Name=Sry-alpha;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000312|EMBL:AAC69336.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9790579; DOI=10.1007/s004380050839;
RA   Ibnsouda S., Ferrer P., Vincent A.;
RT   "Conservation of read-through transcription of the Drosophila serendipity
RT   genes during evolution is gratuitous.";
RL   Mol. Gen. Genet. 259:484-490(1998).
CC   -!- FUNCTION: Required for the cellularization of the syncytial blastoderm
CC       embryo. Involved in the localization of the actin filaments just prior
CC       to and during plasma membrane invagination. Sry-alpha together with
CC       nullo and bnk may provide auxiliary functions, by acting both to
CC       stabilize a large and dynamic microfilament structure and regulate its
CC       functions (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Inner membrane-associated and cytoplasmic.
CC       {ECO:0000250}.
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DR   EMBL; AF084637; AAC69336.1; -; Genomic_DNA.
DR   AlphaFoldDB; O77201; -.
DR   SMR; O77201; -.
DR   STRING; 7244.FBpp0225193; -.
DR   eggNOG; ENOG502SBC0; Eukaryota.
DR   GO; GO:0032154; C:cleavage furrow; IEA:EnsemblMetazoa.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR   GO; GO:0007015; P:actin filament organization; IEA:EnsemblMetazoa.
DR   GO; GO:0007349; P:cellularization; IEA:EnsemblMetazoa.
DR   InterPro; IPR008837; Serendipity_A.
DR   Pfam; PF05482; Serendipity_A; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; Developmental protein; Membrane.
FT   CHAIN           1..537
FT                   /note="Serendipity locus protein alpha"
FT                   /id="PRO_0000072200"
SQ   SEQUENCE   537 AA;  60999 MW;  FB017E1A9E0F35BB CRC64;
     MDKLYLQLNL CTDIIEKGAT CHTAKIAWLN EFCAAFHTFA SKFKSYLIEL APKNELEGNI
     RIHVETIYLC FTQVITCITQ LERTINIEGT LAAGAQLLAT RTHFLDRIDW CLRRLQASVY
     QLAEEAIAST PVKLEDLSFV ELLDLALDKL ETYSEIVPAQ SQAEQEDSDE IDQLVDHVNH
     LIKHALAFAN VALESDKKAL SAIYETVLEE SGIFEKNFKT HNPNRRKLEA LSLQPALYSL
     ETYLNEALFD LIFTSMFDTE KASIKRLRNV LQSCESSGAV DGLLSDFDIN VDRIQQIGIF
     AIAFTQDVKT KTIIRSCLAS LESLDACIVP AFQLQTTSLA SYHADILEHH FRQELMVFRN
     VIHEIIDSRA LINNYLDILA ESIDNAEKLY PKGYLLQVAQ MGNVIYQHFQ LRANNQELIA
     DEEGKRLHQD FVAILHECQA VLEISVHVDL KRIIKRLKIL YSILAKLRDV CDKLVYERAM
     SNNEKSMTTS TKLRQHSFAN PEIGHTIANC NRTDSSDSLS HESDLISFQL TEILRIT