SRYC_DROME
ID SRYC_DROME Reviewed; 869 AA.
AC P15619; Q9VAT4;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Serendipity locus protein H-1;
DE AltName: Full=Protein pourquoi-pas;
DE AltName: Full=Protein wings-down;
GN Name=wdn; Synonyms=pqp, sry h-1, Sry-c; ORFNames=CG1454;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S;
RX PubMed=3141791; DOI=10.1128/mcb.8.10.4459-4468.1988;
RA Vincent A., Kejzlarova-Lepesant J., Segalat L., Yanicostas C.,
RA Lepesant J.-A.;
RT "sry h-1, a new Drosophila melanogaster multifingered protein gene showing
RT maternal and zygotic expression.";
RL Mol. Cell. Biol. 8:4459-4468(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=1592256; DOI=10.1101/gad.6.6.1019;
RA Segalat L., Perichon R., Bouly J.-P., Lepesant J.-A.;
RT "The Drosophila pourquoi-pas?/wings-down zinc finger protein: oocyte
RT nucleus localization and embryonic requirement.";
RL Genes Dev. 6:1019-1029(1992).
CC -!- FUNCTION: May belong to a complex set of multifingered proteins which
CC play an important role in gene activation or regulation at early
CC embryonic stages through a maximal accumulation of their transcripts
CC (or protein product) in the mature oocyte.
CC {ECO:0000269|PubMed:3141791}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1592256}.
CC -!- TISSUE SPECIFICITY: Distribution varies between nurse cells and the
CC oocyte during oogenesis. Weakly expressed in follicle and border cells.
CC {ECO:0000269|PubMed:1592256}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed from stage 1 of oogenesis. Expressed at a low level in the
CC embryo from the tenth nuclear division to the end of cellularization in
CC all cell nuclei except those of pole cells. Also weakly expressed in
CC the embryo after germ-band retraction, and in larvae (at protein
CC level). {ECO:0000269|PubMed:1592256, ECO:0000269|PubMed:3141791}.
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DR EMBL; M23391; AAA28487.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56815.1; -; Genomic_DNA.
DR EMBL; AY058690; AAL13919.1; -; mRNA.
DR PIR; A30817; A30817.
DR RefSeq; NP_476900.1; NM_057552.4.
DR AlphaFoldDB; P15619; -.
DR SMR; P15619; -.
DR BioGRID; 68274; 16.
DR IntAct; P15619; 12.
DR STRING; 7227.FBpp0084725; -.
DR PaxDb; P15619; -.
DR EnsemblMetazoa; FBtr0085356; FBpp0084725; FBgn0005642.
DR GeneID; 43398; -.
DR KEGG; dme:Dmel_CG1454; -.
DR CTD; 43398; -.
DR FlyBase; FBgn0005642; wdn.
DR VEuPathDB; VectorBase:FBgn0005642; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000168270; -.
DR HOGENOM; CLU_014494_0_0_1; -.
DR InParanoid; P15619; -.
DR OMA; FNVTFLR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P15619; -.
DR BioGRID-ORCS; 43398; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43398; -.
DR PRO; PR:P15619; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0005642; Expressed in egg cell and 40 other tissues.
DR Genevisible; P15619; DM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..869
FT /note="Serendipity locus protein H-1"
FT /id="PRO_0000047051"
FT ZN_FING 269..293
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 331..352
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..493
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 120
FT /note="V -> L (in Ref. 1; AAA28487)"
FT /evidence="ECO:0000305"
FT CONFLICT 247..252
FT /note="AASMPP -> RLACR (in Ref. 1; AAA28487)"
FT /evidence="ECO:0000305"
FT CONFLICT 706
FT /note="T -> N (in Ref. 1; AAA28487)"
FT /evidence="ECO:0000305"
FT CONFLICT 750
FT /note="P -> A (in Ref. 1; AAA28487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 869 AA; 95314 MW; 550D0871C6664E70 CRC64;
MEGGKGEGKR MKEEAPSKKL PPKIYGGDAG TPTKAAHDEI LSSLLRINNF DSISSIKDES
LDIDLSACVT ISSASLVNGN SLSSTDFWRV LDESAQNNTE LNLSSDVCRD DLAATSSSTV
PSTLTSDNHS SSEFSVTFLR PEPPNAFTNS PFKKTSSSGT STPVKLSPEQ LHQQHQLQMP
QSQLLQRKPK LPAATAVRLK VFKEEPPEEK HPPEQVVTKV EVCESELLPP SFTIFQQAKS
AESVADAASM PPPAASETKP LEVDPAPLHK CLDCNGLLLE TPDEVAKHEA AAHRLRLTYR
CSECQREFEL LAGLKKHLKT HRTEGRKDTW KKCPDCGKCL KLGSMWMHRK IHSDNKKYQC
DICGQKFVQK INLTHHARIH SSEKPYECPE CQKRFQERSH LQRHQKYHAQ TRSYRCEKCG
KMYKTERCLK VHNLVHLEQR PFACTVCDKS FISNSKLKQH SNIHTGMRPF KCNYCPRDFT
NFPNWLKHTR RRHKVDHKTG EHLENIPSYC SKKSTTNKAQ KAAAAAAAAA AASSAVNPNE
LSASSELKAK ANLTSTAAPA PAKQARKKKQ PQQATLAALG ITLPAGTALQ QVHPVPLAQQ
HQQELTTVLV PLAPPAPKQT KAKRERKQLA PKQLQQKPQL LQQGQPQQSS LEPIPAVPQI
KKEPVQTQGP FLDLHGLSLT SAEELIMEQA LEMEECGLYD APNANTEMGT SDNAISDSAA
ALHFQIKNEL PDELLPDDDF LPCKPSDRLP CPSLESSPFS SPASMELTAV SCASSVAIST
NALPVRSGNY YLPAFTLNAH GKLSSTGNGV QSVTTSLAQT PSVSMVNVPL LVRSNQMLPS
VDTLLFTNQT GGSRFFAGKS ATAATPHLT
