SRY_PANTR
ID SRY_PANTR Reviewed; 204 AA.
AC Q28798; A2T700;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Sex-determining region Y protein;
DE AltName: Full=Testis-determining factor;
GN Name=SRY; Synonyms=TDF;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8355783; DOI=10.1038/364713a0;
RA Whitfield L.S., Lovell-Badge R., Goodfellow P.N.;
RT "Rapid sequence evolution of the mammalian sex-determining gene SRY.";
RL Nature 364:713-715(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hughes J.F., Pyntikova T., Skaletsky H., Minx P.J., Rozen S., Wilson R.K.,
RA Page D.C.;
RT "The DNA sequence of the chimpanzee Y chromosome.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-102.
RX PubMed=9571157; DOI=10.1006/bbrc.1998.8441;
RA Margarit E., Guillen A., Rebordosa C., Vidal-Taboada J.M., Sanchez M.,
RA Ballesta F., Oliva R.;
RT "Identification of conserved potentially regulatory sequences of the SRY
RT gene from 10 different species of mammals.";
RL Biochem. Biophys. Res. Commun. 245:370-377(1998).
CC -!- FUNCTION: Transcriptional regulator that controls a genetic switch in
CC male development. It is necessary and sufficient for initiating male
CC sex determination by directing the development of supporting cell
CC precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
CC Involved in different aspects of gene regulation including promoter
CC activation or repression. Binds to the DNA consensus sequence 5'-
CC [AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation
CC in the minor groove and promotes DNA bending. Also involved in pre-mRNA
CC splicing (By similarity). In male adult brain involved in the
CC maintenance of motor functions of dopaminergic neurons (By similarity).
CC {ECO:0000250|UniProtKB:P36394, ECO:0000250|UniProtKB:Q05066}.
CC -!- SUBUNIT: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-
CC O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its
CC DNA-binding activity. The interaction with KPNB1 is sensitive to
CC dissociation by Ran in the GTP-bound form. Interaction with PARP1
CC impaired its DNA-binding activity. {ECO:0000250|UniProtKB:Q05066}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q05066}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q05066}. Nucleus
CC {ECO:0000250|UniProtKB:Q05066}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=The tenuous nature of sex
CC - Issue 80 of March 2007;
CC URL="https://web.expasy.org/spotlight/back_issues/080";
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DR EMBL; X86380; CAA60140.1; -; Genomic_DNA.
DR EMBL; AY679780; AAT84368.1; -; mRNA.
DR EMBL; DQ977342; ABM91955.1; -; Genomic_DNA.
DR EMBL; AJ222687; CAA10942.1; -; Genomic_DNA.
DR PIR; S35558; S35558.
DR RefSeq; NP_001008988.1; NM_001008988.1.
DR AlphaFoldDB; Q28798; -.
DR SMR; Q28798; -.
DR STRING; 9598.ENSPTRP00000038745; -.
DR PaxDb; Q28798; -.
DR Ensembl; ENSPTRT00000041956; ENSPTRP00000038745; ENSPTRG00000022469.
DR GeneID; 449510; -.
DR KEGG; ptr:449510; -.
DR CTD; 6736; -.
DR VGNC; VGNC:5889; SRY.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000165583; -.
DR HOGENOM; CLU_1209425_0_0_1; -.
DR InParanoid; Q28798; -.
DR OMA; DCTKATH; -.
DR OrthoDB; 369754at2759; -.
DR Proteomes; UP000002277; Chromosome Y.
DR Bgee; ENSPTRG00000022469; Expressed in fibroblast and 1 other tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0030238; P:male sex determination; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:2000020; P:positive regulation of male gonad development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270:SF199; PTHR10270:SF199; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Calmodulin-binding; Cytoplasm; Differentiation; DNA-binding;
KW Nucleus; Reference proteome; Sexual differentiation; Transcription;
KW Transcription regulation.
FT CHAIN 1..204
FT /note="Sex-determining region Y protein"
FT /id="PRO_0000048695"
FT DNA_BIND 60..128
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 175..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 24047 MW; 1892AB538905329D CRC64;
MQSYASAMLS VFNSDDYSPA VQQNIPALRR SSSFLCTESY NSKYQRETGE NSKDSVQDRV
KRPMNAFFVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM LTEAEKWPFF QEAQKLQAMH
REKYPNYKYR PRRKANMLPK NCSLLPADPA SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL
GHLPPINAAS SPQQRDRYSH WTKL
