位置:首页 > 蛋白库 > ABHDD_HUMAN
ABHDD_HUMAN
ID   ABHDD_HUMAN             Reviewed;         337 AA.
AC   Q7L211; B3KWE7; Q8NBW1; Q96JX9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Protein ABHD13 {ECO:0000305};
DE            EC=3.-.-.-;
DE   AltName: Full=Alpha/beta hydrolase domain-containing protein 13 {ECO:0000305};
DE            Short=Abhydrolase domain-containing protein 13 {ECO:0000312|HGNC:HGNC:20293};
GN   Name=ABHD13 {ECO:0000312|HGNC:HGNC:20293}; Synonyms=C13orf6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hippocampus, and Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-length
RT   human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT   libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serine esterase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH70226.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AK075195; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB55387.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK027812; BAB55387.1; ALT_INIT; mRNA.
DR   EMBL; AK124864; BAG54109.1; -; mRNA.
DR   EMBL; AK075195; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL157762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471085; EAX09097.1; -; Genomic_DNA.
DR   EMBL; BC022566; AAH22566.2; -; mRNA.
DR   EMBL; BC070226; AAH70226.1; ALT_INIT; mRNA.
DR   CCDS; CCDS32007.1; -.
DR   RefSeq; NP_116248.2; NM_032859.2.
DR   RefSeq; XP_011519430.1; XM_011521128.2.
DR   AlphaFoldDB; Q7L211; -.
DR   SMR; Q7L211; -.
DR   BioGRID; 124378; 7.
DR   IntAct; Q7L211; 1.
DR   STRING; 9606.ENSP00000365063; -.
DR   ESTHER; human-ABHD13; ABHD13-BEM46.
DR   MEROPS; S09.051; -.
DR   GlyGen; Q7L211; 1 site.
DR   iPTMnet; Q7L211; -.
DR   PhosphoSitePlus; Q7L211; -.
DR   BioMuta; ABHD13; -.
DR   DMDM; 74749881; -.
DR   EPD; Q7L211; -.
DR   jPOST; Q7L211; -.
DR   MassIVE; Q7L211; -.
DR   MaxQB; Q7L211; -.
DR   PaxDb; Q7L211; -.
DR   PeptideAtlas; Q7L211; -.
DR   PRIDE; Q7L211; -.
DR   ProteomicsDB; 68754; -.
DR   Antibodypedia; 25425; 114 antibodies from 20 providers.
DR   DNASU; 84945; -.
DR   Ensembl; ENST00000375898.4; ENSP00000365063.3; ENSG00000139826.6.
DR   GeneID; 84945; -.
DR   KEGG; hsa:84945; -.
DR   MANE-Select; ENST00000375898.4; ENSP00000365063.3; NM_032859.3; NP_116248.2.
DR   UCSC; uc001vqq.4; human.
DR   CTD; 84945; -.
DR   GeneCards; ABHD13; -.
DR   HGNC; HGNC:20293; ABHD13.
DR   HPA; ENSG00000139826; Low tissue specificity.
DR   neXtProt; NX_Q7L211; -.
DR   OpenTargets; ENSG00000139826; -.
DR   PharmGKB; PA134862303; -.
DR   VEuPathDB; HostDB:ENSG00000139826; -.
DR   eggNOG; KOG4391; Eukaryota.
DR   GeneTree; ENSGT00940000158114; -.
DR   HOGENOM; CLU_029375_2_0_1; -.
DR   InParanoid; Q7L211; -.
DR   OMA; PNGGHND; -.
DR   OrthoDB; 1036130at2759; -.
DR   PhylomeDB; Q7L211; -.
DR   TreeFam; TF315122; -.
DR   PathwayCommons; Q7L211; -.
DR   SignaLink; Q7L211; -.
DR   BioGRID-ORCS; 84945; 59 hits in 1078 CRISPR screens.
DR   GenomeRNAi; 84945; -.
DR   Pharos; Q7L211; Tdark.
DR   PRO; PR:Q7L211; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q7L211; protein.
DR   Bgee; ENSG00000139826; Expressed in monocyte and 153 other tissues.
DR   ExpressionAtlas; Q7L211; baseline and differential.
DR   Genevisible; Q7L211; HS.
DR   GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR   GO; GO:0002084; P:protein depalmitoylation; IEA:Ensembl.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR022742; Hydrolase_4.
DR   Pfam; PF12146; Hydrolase_4; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Protein ABHD13"
FT                   /id="PRO_0000281076"
FT   TRANSMEM        37..57
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        193
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        268
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        298
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        299
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        43
FT                   /note="I -> V (in Ref. 2; AK075195)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80
FT                   /note="M -> I (in Ref. 2; AK075195)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   337 AA;  38548 MW;  D8298BF81784827F CRC64;
     MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF ISIAGILYKF
     QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN LILIRYTGDN SPYSPTIIYF
     HGNAGNIGHR LPNALLMLVN LKVNLLLVDY RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP
     DLDKTKIFLF GRSLGGAVAI HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL
     WCYKNKFLSY RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND
     TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024