ABHDD_HUMAN
ID ABHDD_HUMAN Reviewed; 337 AA.
AC Q7L211; B3KWE7; Q8NBW1; Q96JX9;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Protein ABHD13 {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 13 {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 13 {ECO:0000312|HGNC:HGNC:20293};
GN Name=ABHD13 {ECO:0000312|HGNC:HGNC:20293}; Synonyms=C13orf6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serine esterase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH70226.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AK075195; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB55387.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK027812; BAB55387.1; ALT_INIT; mRNA.
DR EMBL; AK124864; BAG54109.1; -; mRNA.
DR EMBL; AK075195; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL157762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471085; EAX09097.1; -; Genomic_DNA.
DR EMBL; BC022566; AAH22566.2; -; mRNA.
DR EMBL; BC070226; AAH70226.1; ALT_INIT; mRNA.
DR CCDS; CCDS32007.1; -.
DR RefSeq; NP_116248.2; NM_032859.2.
DR RefSeq; XP_011519430.1; XM_011521128.2.
DR AlphaFoldDB; Q7L211; -.
DR SMR; Q7L211; -.
DR BioGRID; 124378; 7.
DR IntAct; Q7L211; 1.
DR STRING; 9606.ENSP00000365063; -.
DR ESTHER; human-ABHD13; ABHD13-BEM46.
DR MEROPS; S09.051; -.
DR GlyGen; Q7L211; 1 site.
DR iPTMnet; Q7L211; -.
DR PhosphoSitePlus; Q7L211; -.
DR BioMuta; ABHD13; -.
DR DMDM; 74749881; -.
DR EPD; Q7L211; -.
DR jPOST; Q7L211; -.
DR MassIVE; Q7L211; -.
DR MaxQB; Q7L211; -.
DR PaxDb; Q7L211; -.
DR PeptideAtlas; Q7L211; -.
DR PRIDE; Q7L211; -.
DR ProteomicsDB; 68754; -.
DR Antibodypedia; 25425; 114 antibodies from 20 providers.
DR DNASU; 84945; -.
DR Ensembl; ENST00000375898.4; ENSP00000365063.3; ENSG00000139826.6.
DR GeneID; 84945; -.
DR KEGG; hsa:84945; -.
DR MANE-Select; ENST00000375898.4; ENSP00000365063.3; NM_032859.3; NP_116248.2.
DR UCSC; uc001vqq.4; human.
DR CTD; 84945; -.
DR GeneCards; ABHD13; -.
DR HGNC; HGNC:20293; ABHD13.
DR HPA; ENSG00000139826; Low tissue specificity.
DR neXtProt; NX_Q7L211; -.
DR OpenTargets; ENSG00000139826; -.
DR PharmGKB; PA134862303; -.
DR VEuPathDB; HostDB:ENSG00000139826; -.
DR eggNOG; KOG4391; Eukaryota.
DR GeneTree; ENSGT00940000158114; -.
DR HOGENOM; CLU_029375_2_0_1; -.
DR InParanoid; Q7L211; -.
DR OMA; PNGGHND; -.
DR OrthoDB; 1036130at2759; -.
DR PhylomeDB; Q7L211; -.
DR TreeFam; TF315122; -.
DR PathwayCommons; Q7L211; -.
DR SignaLink; Q7L211; -.
DR BioGRID-ORCS; 84945; 59 hits in 1078 CRISPR screens.
DR GenomeRNAi; 84945; -.
DR Pharos; Q7L211; Tdark.
DR PRO; PR:Q7L211; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q7L211; protein.
DR Bgee; ENSG00000139826; Expressed in monocyte and 153 other tissues.
DR ExpressionAtlas; Q7L211; baseline and differential.
DR Genevisible; Q7L211; HS.
DR GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR GO; GO:0002084; P:protein depalmitoylation; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022742; Hydrolase_4.
DR Pfam; PF12146; Hydrolase_4; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..337
FT /note="Protein ABHD13"
FT /id="PRO_0000281076"
FT TRANSMEM 37..57
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT ACT_SITE 193
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 268
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 298
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 43
FT /note="I -> V (in Ref. 2; AK075195)"
FT /evidence="ECO:0000305"
FT CONFLICT 80
FT /note="M -> I (in Ref. 2; AK075195)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 38548 MW; D8298BF81784827F CRC64;
MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF ISIAGILYKF
QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN LILIRYTGDN SPYSPTIIYF
HGNAGNIGHR LPNALLMLVN LKVNLLLVDY RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP
DLDKTKIFLF GRSLGGAVAI HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL
WCYKNKFLSY RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND
TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII
