ID   SSAA1_STAAS             Reviewed;         255 AA.
AC   Q6G6A8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Staphylococcal secretory antigen ssaA1;
DE   Flags: Precursor;
GN   Name=ssaA1; OrderedLocusNames=SAS2452;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Not known; immunogenic protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; BX571857; CAG44268.1; -; Genomic_DNA.
DR   RefSeq; WP_000725225.1; NC_002953.3.
DR   AlphaFoldDB; Q6G6A8; -.
DR   SMR; Q6G6A8; -.
DR   KEGG; sas:SAS2452; -.
DR   HOGENOM; CLU_016043_11_0_9; -.
DR   OMA; NTWGNAN; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007921; CHAP_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50911; CHAP; 1.
PE   3: Inferred from homology;
KW   Repeat; Secreted; Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..255
FT                   /note="Staphylococcal secretory antigen ssaA1"
FT                   /id="PRO_0000045312"
FT   REPEAT          75..78
FT                   /note="1"
FT   REPEAT          88..91
FT                   /note="2"
FT   REPEAT          98..101
FT                   /note="3"
FT   DOMAIN          134..255
FT                   /note="Peptidase C51"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00048"
FT   REGION          75..101
FT                   /note="3 X 4 AA repeats of Y-N-N-Y"
SQ   SEQUENCE   255 AA;  27589 MW;  B433F2B5FD149970 CRC64;
     MKKIVTATIA TAGLATIAFA GHDAQAAEQN NNGYNSNDAQ SYSYTYTIDA QGNYHYTWTG
     NWNPSQLTQN NTYYYNNYNT YSYNNASYNN YYNHSYQYNN YTNNSQTATN NYYTGGSGAS
     YSTTSNNVHV TTTAAPSSNG RSISNGYASG SNLYTSGQCT YYVFDRVGGK IGSTWGNASN
     WANAAASSGY TVNNTPKVGA IMQTTQGYYG HVAYVEGVNS NGSVRVSEMN YGHGAGVVTS
     RTISANQAGS YNFIH