ID   SSAA2_STAA8             Reviewed;         267 AA.
AC   Q2G2J2;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Staphylococcal secretory antigen ssaA2;
DE   Flags: Precursor;
GN   Name=ssaA2; OrderedLocusNames=SAOUHSC_02571;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND INDUCTION.
RC   STRAIN=RN4220;
RX   PubMed=20472795; DOI=10.1128/jb.01452-09;
RA   Sibbald M.J., Winter T., van der Kooi-Pol M.M., Buist G., Tsompanidou E.,
RA   Bosma T., Schafer T., Ohlsen K., Hecker M., Antelmann H., Engelmann S.,
RA   van Dijl J.M.;
RT   "Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in
RT   Staphylococcus aureus.";
RL   J. Bacteriol. 192:3788-3800(2010).
CC   -!- FUNCTION: Not known; immunogenic protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20472795}.
CC   -!- INDUCTION: More protein is secreted in a secG or double secG/secY2
CC       mutant (at protein level). {ECO:0000269|PubMed:20472795}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000253; ABD31583.1; -; Genomic_DNA.
DR   RefSeq; WP_000717381.1; NZ_LS483365.1.
DR   RefSeq; YP_501032.1; NC_007795.1.
DR   AlphaFoldDB; Q2G2J2; -.
DR   SMR; Q2G2J2; -.
DR   STRING; 1280.SAXN108_2547; -.
DR   EnsemblBacteria; ABD31583; ABD31583; SAOUHSC_02571.
DR   GeneID; 3921568; -.
DR   KEGG; sao:SAOUHSC_02571; -.
DR   PATRIC; fig|93061.5.peg.2319; -.
DR   eggNOG; COG3942; Bacteria.
DR   HOGENOM; CLU_016043_11_0_9; -.
DR   OMA; WSPERFN; -.
DR   PRO; PR:Q2G2J2; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR007921; CHAP_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF05257; CHAP; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50911; CHAP; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome; Repeat; Secreted; Signal; Virulence.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..267
FT                   /note="Staphylococcal secretory antigen ssaA2"
FT                   /id="PRO_0000414599"
FT   REPEAT          83..85
FT                   /note="1"
FT   REPEAT          86..88
FT                   /note="2"
FT   REPEAT          89..91
FT                   /note="3"
FT   REPEAT          95..97
FT                   /note="4"
FT   REPEAT          101..103
FT                   /note="5"
FT   REPEAT          104..106
FT                   /note="6"
FT   REPEAT          113..115
FT                   /note="7"
FT   DOMAIN          146..267
FT                   /note="Peptidase C51"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00048"
FT   REGION          83..115
FT                   /note="7 X 3 AA repeats of Y-[NS]-N"
SQ   SEQUENCE   267 AA;  29327 MW;  F0F72FEE2A32897A CRC64;
     MKKIATATIA TAGFATIAIA SGNQAHASEQ DNYGYNPNDP TSYSYTYTID AQGNYHYTWK
     GNWHPSQLNQ DNGYYSYYYY NGYNNYNNYN NGYSYNNYSR YNNYSNNNQS YNYNNYNSYN
     TNSYRTGGLG ASYSTSSNNV QVTTTMAPSS NGRSISSGYT SGRNLYTSGQ CTYYVFDRVG
     GKIGSTWGNA SNWANAAARA GYTVNNTPKA GAIMQTTQGA YGHVAYVESV NSNGSVRVSE
     MNYGYGPGVV TSRTISASQA AGYNFIH