ID   SSAA2_STAAS             Reviewed;         269 AA.
AC   Q6G723;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Staphylococcal secretory antigen ssaA2;
DE   Flags: Precursor;
GN   Name=ssaA2; OrderedLocusNames=SAS2189;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Not known; immunogenic protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; BX571857; CAG44000.1; -; Genomic_DNA.
DR   RefSeq; WP_000717388.1; NC_002953.3.
DR   AlphaFoldDB; Q6G723; -.
DR   SMR; Q6G723; -.
DR   KEGG; sas:SAS2189; -.
DR   HOGENOM; CLU_016043_11_0_9; -.
DR   OMA; WSPERFN; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007921; CHAP_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF05257; CHAP; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50911; CHAP; 1.
PE   3: Inferred from homology;
KW   Repeat; Secreted; Signal; Virulence.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..269
FT                   /note="Staphylococcal secretory antigen ssaA2"
FT                   /id="PRO_0000045318"
FT   REPEAT          83..85
FT                   /note="1"
FT   REPEAT          88..90
FT                   /note="2"
FT   REPEAT          91..93
FT                   /note="3"
FT   REPEAT          97..99
FT                   /note="4"
FT   REPEAT          103..105
FT                   /note="5"
FT   REPEAT          106..108
FT                   /note="6"
FT   REPEAT          115..117
FT                   /note="7"
FT   DOMAIN          148..269
FT                   /note="Peptidase C51"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00048"
FT   REGION          83..115
FT                   /note="7 X 3 AA repeats of Y-[NS]-N"
SQ   SEQUENCE   269 AA;  29604 MW;  36E341415CA5F2FD CRC64;
     MKKIATATIA TAGFATIAIA SGNQAHASEQ DNYGYNPNDP TSYSYTYTID AQGNYHYTWK
     GNWHPSQLNQ DNGYYSYYYY NGYNNYNYNN YNNGYSYNNY SRYNNYSNNN QSYNYNNYNS
     YNTNSYRTGG LGASYSTSSN NVQVTTTMAP SSNGRSISSG YTSGRNLYTS GQCTYYVFDR
     VGGKIGSTWG NASNWANAAA RAGYTVNNTP KAGAIMQTTQ GAYGHVAYVE SVNSNGSVRV
     SEMNYGYGPG VVTSRTISAS QAAGYNFIH