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SSAA_STAA8
ID   SSAA_STAA8              Reviewed;         255 AA.
AC   Q2FV55;
DT   22-AUG-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Staphylococcal secretory antigen SsaA;
DE   Flags: Precursor;
GN   Name=ssaA; OrderedLocusNames=SAOUHSC_02883;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   REGULATION BY YYCG/YYCF.
RX   PubMed=14762013; DOI=10.1128/jb.186.4.1175-1181.2004;
RA   Dubrac S., Msadek T.;
RT   "Identification of genes controlled by the essential YycG/YycF two-
RT   component system of Staphylococcus aureus.";
RL   J. Bacteriol. 186:1175-1181(2004).
CC   -!- FUNCTION: Not known; immunogenic protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: Activated by two-component regulatory system YycG/YycF.
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DR   EMBL; CP000253; ABD31880.1; -; Genomic_DNA.
DR   RefSeq; WP_000725225.1; NZ_LS483365.1.
DR   RefSeq; YP_501337.1; NC_007795.1.
DR   AlphaFoldDB; Q2FV55; -.
DR   SMR; Q2FV55; -.
DR   STRING; 1280.SAXN108_2817; -.
DR   EnsemblBacteria; ABD31880; ABD31880; SAOUHSC_02883.
DR   GeneID; 3921553; -.
DR   KEGG; sao:SAOUHSC_02883; -.
DR   PATRIC; fig|93061.5.peg.2606; -.
DR   eggNOG; COG3942; Bacteria.
DR   HOGENOM; CLU_016043_11_0_9; -.
DR   OMA; NTWGNAN; -.
DR   PRO; PR:Q2FV55; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007921; CHAP_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50911; CHAP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Secreted; Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..255
FT                   /note="Staphylococcal secretory antigen SsaA"
FT                   /id="PRO_0000247965"
FT   REPEAT          75..78
FT                   /note="1"
FT   REPEAT          88..91
FT                   /note="2"
FT   REPEAT          98..101
FT                   /note="3"
FT   DOMAIN          134..255
FT                   /note="Peptidase C51"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00048"
FT   REGION          75..101
FT                   /note="3 X 4 AA repeats of Y-N-N-Y"
SQ   SEQUENCE   255 AA;  27589 MW;  B433F2B5FD149970 CRC64;
     MKKIVTATIA TAGLATIAFA GHDAQAAEQN NNGYNSNDAQ SYSYTYTIDA QGNYHYTWTG
     NWNPSQLTQN NTYYYNNYNT YSYNNASYNN YYNHSYQYNN YTNNSQTATN NYYTGGSGAS
     YSTTSNNVHV TTTAAPSSNG RSISNGYASG SNLYTSGQCT YYVFDRVGGK IGSTWGNASN
     WANAAASSGY TVNNTPKVGA IMQTTQGYYG HVAYVEGVNS NGSVRVSEMN YGHGAGVVTS
     RTISANQAGS YNFIH
 
 
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