SSAA_STAA8
ID SSAA_STAA8 Reviewed; 255 AA.
AC Q2FV55;
DT 22-AUG-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Staphylococcal secretory antigen SsaA;
DE Flags: Precursor;
GN Name=ssaA; OrderedLocusNames=SAOUHSC_02883;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
RN [2]
RP REGULATION BY YYCG/YYCF.
RX PubMed=14762013; DOI=10.1128/jb.186.4.1175-1181.2004;
RA Dubrac S., Msadek T.;
RT "Identification of genes controlled by the essential YycG/YycF two-
RT component system of Staphylococcus aureus.";
RL J. Bacteriol. 186:1175-1181(2004).
CC -!- FUNCTION: Not known; immunogenic protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- INDUCTION: Activated by two-component regulatory system YycG/YycF.
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DR EMBL; CP000253; ABD31880.1; -; Genomic_DNA.
DR RefSeq; WP_000725225.1; NZ_LS483365.1.
DR RefSeq; YP_501337.1; NC_007795.1.
DR AlphaFoldDB; Q2FV55; -.
DR SMR; Q2FV55; -.
DR STRING; 1280.SAXN108_2817; -.
DR EnsemblBacteria; ABD31880; ABD31880; SAOUHSC_02883.
DR GeneID; 3921553; -.
DR KEGG; sao:SAOUHSC_02883; -.
DR PATRIC; fig|93061.5.peg.2606; -.
DR eggNOG; COG3942; Bacteria.
DR HOGENOM; CLU_016043_11_0_9; -.
DR OMA; NTWGNAN; -.
DR PRO; PR:Q2FV55; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR007921; CHAP_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS50911; CHAP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Secreted; Signal; Virulence.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..255
FT /note="Staphylococcal secretory antigen SsaA"
FT /id="PRO_0000247965"
FT REPEAT 75..78
FT /note="1"
FT REPEAT 88..91
FT /note="2"
FT REPEAT 98..101
FT /note="3"
FT DOMAIN 134..255
FT /note="Peptidase C51"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00048"
FT REGION 75..101
FT /note="3 X 4 AA repeats of Y-N-N-Y"
SQ SEQUENCE 255 AA; 27589 MW; B433F2B5FD149970 CRC64;
MKKIVTATIA TAGLATIAFA GHDAQAAEQN NNGYNSNDAQ SYSYTYTIDA QGNYHYTWTG
NWNPSQLTQN NTYYYNNYNT YSYNNASYNN YYNHSYQYNN YTNNSQTATN NYYTGGSGAS
YSTTSNNVHV TTTAAPSSNG RSISNGYASG SNLYTSGQCT YYVFDRVGGK IGSTWGNASN
WANAAASSGY TVNNTPKVGA IMQTTQGYYG HVAYVEGVNS NGSVRVSEMN YGHGAGVVTS
RTISANQAGS YNFIH