ID   SSAA_STAAE              Reviewed;         255 AA.
AC   Q53587; A6QK56;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Staphylococcal secretory antigen SsaA;
DE   Flags: Precursor;
GN   Name=ssaA; OrderedLocusNames=NWMN_2466;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16020541; DOI=10.1074/jbc.m505070200;
RA   Pelz A., Wieland K.-P., Putzbach K., Hentschel P., Albert K., Goetz F.;
RT   "Structure and biosynthesis of staphyloxanthin from Staphylococcus
RT   aureus.";
RL   J. Biol. Chem. 280:32493-32498(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: Not known; immunogenic protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: Activated by two-component regulatory system YycG/YycF.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X97985; CAA66624.1; -; Genomic_DNA.
DR   EMBL; AP009351; BAF68738.1; -; Genomic_DNA.
DR   RefSeq; WP_000725225.1; NZ_CP023390.1.
DR   AlphaFoldDB; Q53587; -.
DR   SMR; Q53587; -.
DR   EnsemblBacteria; BAF68738; BAF68738; NWMN_2466.
DR   KEGG; sae:NWMN_2466; -.
DR   HOGENOM; CLU_016043_11_0_9; -.
DR   OMA; NTWGNAN; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007921; CHAP_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50911; CHAP; 1.
PE   3: Inferred from homology;
KW   Repeat; Secreted; Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..255
FT                   /note="Staphylococcal secretory antigen SsaA"
FT                   /id="PRO_0000045307"
FT   REPEAT          75..78
FT                   /note="1"
FT   REPEAT          88..91
FT                   /note="2"
FT   REPEAT          98..101
FT                   /note="3"
FT   DOMAIN          134..255
FT                   /note="Peptidase C51"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00048"
FT   REGION          75..101
FT                   /note="3 X 4 AA repeats of Y-N-N-Y"
SQ   SEQUENCE   255 AA;  27589 MW;  B433F2B5FD149970 CRC64;
     MKKIVTATIA TAGLATIAFA GHDAQAAEQN NNGYNSNDAQ SYSYTYTIDA QGNYHYTWTG
     NWNPSQLTQN NTYYYNNYNT YSYNNASYNN YYNHSYQYNN YTNNSQTATN NYYTGGSGAS
     YSTTSNNVHV TTTAAPSSNG RSISNGYASG SNLYTSGQCT YYVFDRVGGK IGSTWGNASN
     WANAAASSGY TVNNTPKVGA IMQTTQGYYG HVAYVEGVNS NGSVRVSEMN YGHGAGVVTS
     RTISANQAGS YNFIH