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SSAJ_SALT1
ID   SSAJ_SALT1              Reviewed;         249 AA.
AC   D0ZWT5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Secretion system apparatus lipoprotein SsaJ;
DE   Flags: Precursor;
GN   Name=ssaJ; OrderedLocusNames=STM14_1705;
OS   Salmonella typhimurium (strain 14028s / SGSC 2262).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=588858;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=19897643; DOI=10.1128/jb.01233-09;
RA   Jarvik T., Smillie C., Groisman E.A., Ochman H.;
RT   "Short-term signatures of evolutionary change in the Salmonella enterica
RT   serovar typhimurium 14028 genome.";
RL   J. Bacteriol. 192:560-567(2010).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=12438395; DOI=10.1128/iai.70.12.7126-7135.2002;
RA   Browne S.H., Lesnick M.L., Guiney D.G.;
RT   "Genetic requirements for Salmonella-induced cytopathology in human
RT   monocyte-derived macrophages.";
RL   Infect. Immun. 70:7126-7135(2002).
CC   -!- FUNCTION: Component of Salmonella pathogenicity island 2 (SPI-2) type
CC       III secretion system, required for secretion of some type III-secreted
CC       effectors including the SpvB exotoxin.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000255|PROSITE-ProRule:PRU00303}.
CC   -!- DISRUPTION PHENOTYPE: 25-fold reduction in cytopathic effects in human
CC       monocyte-derived macrophages. {ECO:0000269|PubMed:12438395}.
CC   -!- SIMILARITY: Belongs to the YscJ lipoprotein family. {ECO:0000305}.
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DR   EMBL; CP001363; ACY88183.1; -; Genomic_DNA.
DR   RefSeq; WP_000862874.1; NZ_CP043402.1.
DR   AlphaFoldDB; D0ZWT5; -.
DR   SMR; D0ZWT5; -.
DR   EnsemblBacteria; ACY88183; ACY88183; STM14_1705.
DR   KEGG; seo:STM14_1705; -.
DR   PATRIC; fig|588858.6.peg.1639; -.
DR   HOGENOM; CLU_073268_1_0_6; -.
DR   OMA; GRIQQMV; -.
DR   BioCyc; SENT588858:STM14_RS07900-MON; -.
DR   Proteomes; UP000002695; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR006182; FliF_N_dom.
DR   InterPro; IPR003282; T3SS_HrcJ/YscJ.
DR   InterPro; IPR043427; YscJ/FliF.
DR   PANTHER; PTHR30046; PTHR30046; 1.
DR   Pfam; PF01514; YscJ_FliF; 1.
DR   PRINTS; PR01338; TYPE3OMKPROT.
DR   TIGRFAMs; TIGR02544; III_secr_YscJ; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Protein transport;
KW   Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..249
FT                   /note="Secretion system apparatus lipoprotein SsaJ"
FT                   /id="PRO_0000410495"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   249 AA;  28521 MW;  A6999389900AA641 CRC64;
     MKVHRIVFLT VLTFFLTACD VDLYRSLPED EANQMLALLM QHHIDAEKKQ EEDGVTLRVE
     QSQFINAVEL LRLNGYPHRQ FTTADKMFPA NQLVVSPQEE QQKINFLKEQ RIEGMLSQME
     GVINAKVTIA LPTYDEGSNA SPSSVAVFIK YSPQVNMEAF RVKIKDLIEM SIPGLQYSKI
     SILMQPAEFR MVADVPARQT FWIMDVINAN KGKVVKWLMK YPYPLMLSLT GLLLGVGILI
     GYFCLRRRF
 
 
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