ID   SSAV_SALDC              Reviewed;         681 AA.
AC   B5FII7;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Secretion system apparatus protein SsaV;
GN   Name=ssaV; OrderedLocusNames=SeD_A1929;
OS   Salmonella dublin (strain CT_02021853).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=439851;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT_02021853;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=Lane;
RX   PubMed=12438395; DOI=10.1128/iai.70.12.7126-7135.2002;
RA   Browne S.H., Lesnick M.L., Guiney D.G.;
RT   "Genetic requirements for Salmonella-induced cytopathology in human
RT   monocyte-derived macrophages.";
RL   Infect. Immun. 70:7126-7135(2002).
CC   -!- FUNCTION: Component of Salmonella pathogenicity island 2 (SPI-2) type
CC       III secretion system, required for secretion of some type III-secreted
CC       effectors including the SpvB exotoxin.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: 100-fold reduction in cytopathic effects in human
CC       monocyte-derived macrophages, loss of polymerization of G- to F-actin
CC       in macrophages. {ECO:0000269|PubMed:12438395}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
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DR   EMBL; CP001144; ACH76678.1; -; Genomic_DNA.
DR   RefSeq; WP_001258231.1; NC_011205.1.
DR   AlphaFoldDB; B5FII7; -.
DR   SMR; B5FII7; -.
DR   KEGG; sed:SeD_A1929; -.
DR   HOGENOM; CLU_015346_3_0_6; -.
DR   OMA; ECGHLPP; -.
DR   Proteomes; UP000008322; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.10.8.540; -; 1.
DR   Gene3D; 3.40.30.60; -; 1.
DR   Gene3D; 3.40.50.12790; -; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   InterPro; IPR006302; T3SS_HrcV.
DR   PANTHER; PTHR30161; PTHR30161; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   TIGRFAMs; TIGR01399; hrcV; 1.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..681
FT                   /note="Secretion system apparatus protein SsaV"
FT                   /id="PRO_0000410493"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   681 AA;  75322 MW;  C9226C9F9A16114A CRC64;
     MRSWLGEGVR AQQWLSVCAG RQDMVLATVL LIAIVMMLLP LPTWMVDILI TINLMFSVIL
     LLIAIYLSDP LDLSVFPSLL LITTLYRLSL TISTSRLVLL QHNAGNIVDA FGKFVVGGNL
     TVGLVVFTII TIVQFIVITK GIERVAEVSA RFSLDGMPGK QMSIDGDLRA GVIDADHART
     LRQHVQQESR FLGAMDGAMK FVKGDTIAGI IVVLVNIIGG IIIAIVQYDM SMSEAVHTYS
     VLSIGDGLCG QIPSLLISLS AGIIVTRVPG EKRQNLATEL SSQIARQPQS LILTAVVLML
     LALIPGFPFI TLAFFSALLA LPIILIRRKK SVVSANGVEA PEKDSMVPGA CPLILRLSPT
     LHSADLIRDI DAMRWFLFED TGVPLPEVNI EVLPEPTEKL TVLLYQEPVF SLSIPAQADY
     LLIGADASVV GDSQTLPNGM GQICWLTKDM AHKAQGFGLD VFAGSQRISA LLKCVLLRHM
     GEFIGVQETR YLMNAMEKNY SELVKELQRQ LPINKIAETL QRLVSERVSI RDLRLIFGTL
     IDWAPREKDV LMLTEYVRIA LRRHILRRLN PEGKPLPILR IGEGIENLVR ESIRQTAMGT
     YTALSSRHKT QILQLIEQAL KQSAKLFIVT SVDTRRFLRK ITEATLFDVP ILSWQELGEE
     SLIQVVESID LSEEELADNE E