ABHDD_MOUSE
ID ABHDD_MOUSE Reviewed; 337 AA.
AC Q80UX8; Q8BXS1; Q9D0V5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein ABHD13 {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 13 {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 13 {ECO:0000312|MGI:MGI:1916154};
GN Name=Abhd13 {ECO:0000312|MGI:MGI:1916154};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serine esterase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31905.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK004375; BAB23280.2; -; mRNA.
DR EMBL; AK044407; BAC31905.1; ALT_INIT; mRNA.
DR EMBL; BC043690; AAH43690.1; -; mRNA.
DR CCDS; CCDS40217.1; -.
DR RefSeq; NP_001074588.1; NM_001081119.1.
DR RefSeq; NP_081144.1; NM_026868.1.
DR AlphaFoldDB; Q80UX8; -.
DR SMR; Q80UX8; -.
DR STRING; 10090.ENSMUSP00000116130; -.
DR ChEMBL; CHEMBL3259493; -.
DR ESTHER; mouse-Q80UX8; ABHD13-BEM46.
DR MEROPS; S09.051; -.
DR GlyGen; Q80UX8; 1 site.
DR iPTMnet; Q80UX8; -.
DR PhosphoSitePlus; Q80UX8; -.
DR EPD; Q80UX8; -.
DR MaxQB; Q80UX8; -.
DR PaxDb; Q80UX8; -.
DR PeptideAtlas; Q80UX8; -.
DR PRIDE; Q80UX8; -.
DR ProteomicsDB; 285748; -.
DR Antibodypedia; 25425; 114 antibodies from 20 providers.
DR DNASU; 68904; -.
DR Ensembl; ENSMUST00000048216; ENSMUSP00000036730; ENSMUSG00000040396.
DR Ensembl; ENSMUST00000139793; ENSMUSP00000116130; ENSMUSG00000040396.
DR GeneID; 68904; -.
DR KEGG; mmu:68904; -.
DR UCSC; uc009kum.1; mouse.
DR CTD; 84945; -.
DR MGI; MGI:1916154; Abhd13.
DR VEuPathDB; HostDB:ENSMUSG00000040396; -.
DR eggNOG; KOG4391; Eukaryota.
DR GeneTree; ENSGT00940000158114; -.
DR HOGENOM; CLU_029375_2_0_1; -.
DR InParanoid; Q80UX8; -.
DR OMA; PNGGHND; -.
DR OrthoDB; 1036130at2759; -.
DR PhylomeDB; Q80UX8; -.
DR TreeFam; TF315122; -.
DR BioGRID-ORCS; 68904; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Abhd13; mouse.
DR PRO; PR:Q80UX8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q80UX8; protein.
DR Bgee; ENSMUSG00000040396; Expressed in ear vesicle and 222 other tissues.
DR Genevisible; Q80UX8; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0032839; C:dendrite cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IDA:UniProtKB.
DR GO; GO:0002084; P:protein depalmitoylation; IDA:UniProtKB.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022742; Hydrolase_4.
DR Pfam; PF12146; Hydrolase_4; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Hydrolase; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..337
FT /note="Protein ABHD13"
FT /id="PRO_0000281077"
FT TRANSMEM 37..57
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT ACT_SITE 193
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 268
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 298
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 337 AA; 38525 MW; 0EAA241B44567B09 CRC64;
MEKSWMLWSF IERWLLALAS WSWALCRISL LPLIVTFHLY GGIVLLLLIF VSIAGILYKF
QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGVRLN LILVRYTGDN SPYCPTIIYF
HGNAGNIGHR LPNALLMLVN LRVNLVLVDY RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP
DLDKTKVFLF GRSLGGAVAI HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL
WCYKNKFLSY RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND
TWQCQGYFTA LEQFIKEVIK SHSPEDMTKT SSNVTII
