SSB_HAEIN
ID SSB_HAEIN Reviewed; 168 AA.
AC P44409;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Single-stranded DNA-binding protein {ECO:0000255|HAMAP-Rule:MF_00984};
DE Short=SSB {ECO:0000255|HAMAP-Rule:MF_00984};
GN Name=ssb; OrderedLocusNames=HI_0250;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NTHi TN106;
RX PubMed=8063092; DOI=10.1016/0378-1119(94)90841-9;
RA Jarosik G.P., Hansen E.J.;
RT "Cloning and sequencing of the Haemophilus influenzae ssb gene encoding
RT single-strand DNA-binding protein.";
RL Gene 146:101-103(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Plays an important role in DNA replication, recombination and
CC repair. Binds to ssDNA and to an array of partner proteins to recruit
CC them to their sites of action during DNA metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_00984}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00984}.
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DR EMBL; L42023; AAC21916.1; -; Genomic_DNA.
DR EMBL; U04997; AAA60461.1; -; Genomic_DNA.
DR PIR; E64057; E64057.
DR RefSeq; NP_438419.1; NC_000907.1.
DR RefSeq; WP_005694052.1; NC_000907.1.
DR AlphaFoldDB; P44409; -.
DR SMR; P44409; -.
DR STRING; 71421.HI_0250; -.
DR PRIDE; P44409; -.
DR EnsemblBacteria; AAC21916; AAC21916; HI_0250.
DR KEGG; hin:HI_0250; -.
DR PATRIC; fig|71421.8.peg.265; -.
DR eggNOG; COG0629; Bacteria.
DR HOGENOM; CLU_078758_0_2_6; -.
DR OMA; SGSVKCR; -.
DR PhylomeDB; P44409; -.
DR BioCyc; HINF71421:G1GJ1-264-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0009295; C:nucleoid; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0051096; P:positive regulation of helicase activity; IBA:GO_Central.
DR CDD; cd04496; SSB_OBF; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00984; SSB; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000424; Primosome_PriB/ssb.
DR InterPro; IPR011344; ssDNA-bd.
DR PANTHER; PTHR10302; PTHR10302; 1.
DR Pfam; PF00436; SSB; 1.
DR PIRSF; PIRSF002070; SSB; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00621; ssb; 1.
DR PROSITE; PS50935; SSB; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA replication; DNA-binding;
KW Reference proteome.
FT CHAIN 1..168
FT /note="Single-stranded DNA-binding protein"
FT /id="PRO_0000096048"
FT DOMAIN 4..109
FT /note="SSB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT REGION 109..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 163..168
FT /note="Important for interaction with partner proteins"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT COMPBIAS 124..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 118..119
FT /note="YG -> FS (in strain: TN106)"
FT VARIANT 121
FT /note="D -> E (in strain: TN106)"
FT VARIANT 124..125
FT /note="GA -> SS (in strain: TN106)"
FT VARIANT 128
FT /note="S -> P (in strain: TN106)"
FT VARIANT 151
FT /note="A -> S (in strain: TN106)"
SQ SEQUENCE 168 AA; 18754 MW; 883DEE51E5623693 CRC64;
MAGINKVIIV GHLGNDPEIR TMPNGDAVAN ISVATSESWN DRNTGERREV TEWHRIVFYR
RQAEICGEYL RKGSQVYVEG RLKTRKWQDQ NGQDRYTTEI QGDVMQMLGG RNQNAGGYGN
DMGGAPQSSY QARQTNNGNS YQSSRPAPQQ AAPQAEPPMD GFDDDIPF
