SSB_HELPY
ID SSB_HELPY Reviewed; 179 AA.
AC O25841;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Single-stranded DNA-binding protein {ECO:0000255|HAMAP-Rule:MF_00984};
DE Short=SSB {ECO:0000255|HAMAP-Rule:MF_00984};
GN Name=ssb; OrderedLocusNames=HP_1245;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Plays an important role in DNA replication, recombination and
CC repair. Binds to ssDNA and to an array of partner proteins to recruit
CC them to their sites of action during DNA metabolism.
CC {ECO:0000255|HAMAP-Rule:MF_00984}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00984}.
CC -!- INTERACTION:
CC O25841; O25365: HP_0650; NbExp=3; IntAct=EBI-527972, EBI-527960;
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DR EMBL; AE000511; AAD08291.1; -; Genomic_DNA.
DR PIR; E64675; E64675.
DR RefSeq; NP_208037.1; NC_000915.1.
DR RefSeq; WP_000482414.1; NC_018939.1.
DR PDB; 2VW9; X-ray; 2.30 A; A/B=1-134.
DR PDBsum; 2VW9; -.
DR AlphaFoldDB; O25841; -.
DR SMR; O25841; -.
DR DIP; DIP-3468N; -.
DR IntAct; O25841; 7.
DR MINT; O25841; -.
DR STRING; 85962.C694_06435; -.
DR PaxDb; O25841; -.
DR DNASU; 900340; -.
DR EnsemblBacteria; AAD08291; AAD08291; HP_1245.
DR KEGG; hpy:HP_1245; -.
DR PATRIC; fig|85962.47.peg.1337; -.
DR eggNOG; COG0629; Bacteria.
DR OMA; SGSVKCR; -.
DR PhylomeDB; O25841; -.
DR EvolutionaryTrace; O25841; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009295; C:nucleoid; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0051096; P:positive regulation of helicase activity; IBA:GO_Central.
DR CDD; cd04496; SSB_OBF; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00984; SSB; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000424; Primosome_PriB/ssb.
DR InterPro; IPR011344; ssDNA-bd.
DR PANTHER; PTHR10302; PTHR10302; 1.
DR Pfam; PF00436; SSB; 1.
DR PIRSF; PIRSF002070; SSB; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00621; ssb; 1.
DR PROSITE; PS50935; SSB; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA damage; DNA recombination; DNA repair; DNA replication;
KW DNA-binding; Reference proteome.
FT CHAIN 1..179
FT /note="Single-stranded DNA-binding protein"
FT /id="PRO_0000096050"
FT DOMAIN 1..106
FT /note="SSB"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT REGION 157..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 174..179
FT /note="Important for interaction with partner proteins"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT STRAND 5..13
FT /evidence="ECO:0007829|PDB:2VW9"
FT STRAND 16..19
FT /evidence="ECO:0007829|PDB:2VW9"
FT STRAND 25..38
FT /evidence="ECO:0007829|PDB:2VW9"
FT STRAND 40..42
FT /evidence="ECO:0007829|PDB:2VW9"
FT STRAND 44..56
FT /evidence="ECO:0007829|PDB:2VW9"
FT HELIX 57..66
FT /evidence="ECO:0007829|PDB:2VW9"
FT STRAND 72..85
FT /evidence="ECO:0007829|PDB:2VW9"
FT STRAND 91..104
FT /evidence="ECO:0007829|PDB:2VW9"
SQ SEQUENCE 179 AA; 20043 MW; 615C301DBE7316FF CRC64;
MFNKVIMVGR LTRNVELKYL PSGSAAATIG LATSRRFKKQ DGTLGEEVCF IDARLFGRTA
EIANQYLSKG SSVLIEGRLT YESWMDQTGK KNSRHTITAD SLQFMDKKSD NPQANAMQDS
IMHENSNNAY PANHNAPSQD PFNQAYAQNA YAKENLQAQP SKYQNSVPEI NIDEEEIPF
