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SSB_MYCLE
ID   SSB_MYCLE               Reviewed;         168 AA.
AC   P46390; O53126;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Single-stranded DNA-binding protein {ECO:0000255|HAMAP-Rule:MF_00984};
DE            Short=SSB {ECO:0000255|HAMAP-Rule:MF_00984};
GN   Name=ssb; OrderedLocusNames=ML2684; ORFNames=MLCB1913.20c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8969512; DOI=10.1099/13500872-142-11-3147;
RA   Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G.,
RA   Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.;
RT   "Gene arrangement and organization in an approximately 76 kb fragment
RT   encompassing the oriC region of the chromosome of Mycobacterium leprae.";
RL   Microbiology 142:3147-3161(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00984}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB53120.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L39923; AAB53120.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL022118; CAA17953.1; -; Genomic_DNA.
DR   EMBL; AL583926; CAC32216.1; -; Genomic_DNA.
DR   PIR; B87245; B87245.
DR   RefSeq; NP_302712.1; NC_002677.1.
DR   RefSeq; WP_010909031.1; NC_002677.1.
DR   PDB; 3AFP; X-ray; 2.05 A; A/B=1-168.
DR   PDB; 3AFQ; X-ray; 2.80 A; A/B/C/D=1-168.
DR   PDBsum; 3AFP; -.
DR   PDBsum; 3AFQ; -.
DR   AlphaFoldDB; P46390; -.
DR   SMR; P46390; -.
DR   STRING; 272631.ML2684; -.
DR   PRIDE; P46390; -.
DR   EnsemblBacteria; CAC32216; CAC32216; CAC32216.
DR   KEGG; mle:ML2684; -.
DR   PATRIC; fig|272631.5.peg.5176; -.
DR   Leproma; ML2684; -.
DR   eggNOG; COG0629; Bacteria.
DR   HOGENOM; CLU_078758_1_0_11; -.
DR   OMA; GQMQERT; -.
DR   EvolutionaryTrace; P46390; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd04496; SSB_OBF; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00984; SSB; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR000424; Primosome_PriB/ssb.
DR   InterPro; IPR011344; ssDNA-bd.
DR   PANTHER; PTHR10302; PTHR10302; 1.
DR   Pfam; PF00436; SSB; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00621; ssb; 1.
DR   PROSITE; PS50935; SSB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome.
FT   CHAIN           1..168
FT                   /note="Single-stranded DNA-binding protein"
FT                   /id="PRO_0000096067"
FT   DOMAIN          1..110
FT                   /note="SSB"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT   REGION          117..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          6..16
FT                   /evidence="ECO:0007829|PDB:3AFP"
FT   STRAND          27..35
FT                   /evidence="ECO:0007829|PDB:3AFP"
FT   STRAND          53..60
FT                   /evidence="ECO:0007829|PDB:3AFP"
FT   HELIX           61..70
FT                   /evidence="ECO:0007829|PDB:3AFP"
FT   STRAND          76..88
FT                   /evidence="ECO:0007829|PDB:3AFP"
FT   STRAND          96..108
FT                   /evidence="ECO:0007829|PDB:3AFP"
FT   STRAND          111..118
FT                   /evidence="ECO:0007829|PDB:3AFP"
SQ   SEQUENCE   168 AA;  17701 MW;  077C62E430623658 CRC64;
     MAGDTTITIV GNLTADPELR FTSSGAAVVN FTVASTPRIY DRQSGEWKDG EALFLRCNIW
     REAAENVAES LTRGARVIVT GRLKQRSFET REGEKRTVVE VEVDEIGPSL RYATAKVNKA
     SRSGGGGGGF GSGSRQAPAQ MSGGVGDDPW GSAPTSGSFG VGDEEPPF
 
 
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