ID   SSB_THEAQ               Reviewed;         264 AA.
AC   Q9KH06;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Single-stranded DNA-binding protein {ECO:0000255|HAMAP-Rule:MF_00984};
DE            Short=SSB {ECO:0000255|HAMAP-Rule:MF_00984};
GN   Name=ssb;
OS   Thermus aquaticus.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=271;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBUNIT.
RC   STRAIN=ATCC 25104 / DSM 625 / JCM 10724 / NBRC 103206 / NCIMB 11243 / YT-1;
RX   PubMed=12368464; DOI=10.1099/00221287-148-10-3307;
RA   Dabrowski S., Olszewski M., Piatek R., Brillowska-Dabrowska A., Konopa G.,
RA   Kur J.;
RT   "Identification and characterization of single-stranded-DNA-binding
RT   proteins from Thermus thermophilus and Thermus aquaticus -- new arrangement
RT   of binding domains.";
RL   Microbiology 148:3307-3315(2002).
CC   -!- FUNCTION: Plays an important role in DNA replication, recombination and
CC       repair. Binds to ssDNA and to an array of partner proteins to recruit
CC       them to their sites of action during DNA metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00984}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:12368464}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF276705; AAF85976.1; -; Genomic_DNA.
DR   RefSeq; WP_053767427.1; NZ_LHCI01000106.1.
DR   PDB; 2FXQ; X-ray; 1.85 A; A=1-264.
DR   PDB; 2IHE; X-ray; 2.10 A; A=1-264.
DR   PDB; 2IHF; X-ray; 1.90 A; A=1-264.
DR   PDBsum; 2FXQ; -.
DR   PDBsum; 2IHE; -.
DR   PDBsum; 2IHF; -.
DR   AlphaFoldDB; Q9KH06; -.
DR   SMR; Q9KH06; -.
DR   EvolutionaryTrace; Q9KH06; -.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd04496; SSB_OBF; 2.
DR   Gene3D; 2.40.50.140; -; 2.
DR   HAMAP; MF_00984; SSB; 2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR000424; Primosome_PriB/ssb.
DR   InterPro; IPR011344; ssDNA-bd.
DR   PANTHER; PTHR10302; PTHR10302; 2.
DR   Pfam; PF00436; SSB; 2.
DR   SUPFAM; SSF50249; SSF50249; 2.
DR   TIGRFAMs; TIGR00621; ssb; 2.
DR   PROSITE; PS50935; SSB; 2.
PE   1: Evidence at protein level;
KW   3D-structure; DNA damage; DNA recombination; DNA repair; DNA replication;
KW   DNA-binding; Repeat.
FT   CHAIN           1..264
FT                   /note="Single-stranded DNA-binding protein"
FT                   /id="PRO_0000096148"
FT   DOMAIN          5..108
FT                   /note="SSB 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT   DOMAIN          128..228
FT                   /note="SSB 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT   REGION          224..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           259..264
FT                   /note="Important for interaction with partner proteins"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00984"
FT   STRAND          5..16
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          19..22
FT                   /evidence="ECO:0007829|PDB:2IHF"
FT   STRAND          28..41
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          47..59
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   HELIX           61..66
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   TURN            67..69
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          75..84
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          97..106
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          129..139
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          142..145
FT                   /evidence="ECO:0007829|PDB:2IHF"
FT   STRAND          151..160
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          171..179
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   HELIX           180..186
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          194..207
FT                   /evidence="ECO:0007829|PDB:2FXQ"
FT   STRAND          213..225
FT                   /evidence="ECO:0007829|PDB:2FXQ"
SQ   SEQUENCE   264 AA;  30029 MW;  CF0AB49B5AA6A454 CRC64;
     MARGLNQVFL IGTLTARPDM RYTPGGLAIL DLNLAGQDAF TDESGQEREV PWYHRVRLLG
     RQAEMWGDLL EKGQLIFVEG RLEYRQWEKD GEKKSEVQVR AEFIDPLEGR GRETLEDARG
     QPRLRRALNQ VILMGNLTRD PDLRYTPQGT AVVRLGLAVN ERRRGQEEER THFLEVQAWR
     ELAEWASELR KGDGLLVIGR LVNDSWTSSS GERRFQTRVE ALRLERPTRG PAQAGGSRPP
     TVQTGGVDID EGLEDFPPEE DLPF