SSCP_HYPVG
ID SSCP_HYPVG Reviewed; 147 AA.
AC G9MQD3;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 1.
DT 03-AUG-2022, entry version 29.
DE RecName: Full=Effector TSP1 {ECO:0000303|PubMed:34547313};
DE AltName: Full=Small secreted cysteine-rich protein {ECO:0000303|PubMed:25681119};
DE Short=SSCP {ECO:0000303|PubMed:25681119};
DE Flags: Precursor;
GN Name=TSP1 {ECO:0000303|PubMed:34547313};
GN ORFNames=TRIVIDRAFT_215947 {ECO:0000312|EMBL:EHK24054.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000312|Proteomes:UP000007115};
RN [1] {ECO:0000312|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000312|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=25681119; DOI=10.1074/mcp.m114.046607;
RA Lamdan N.L., Shalaby S., Ziv T., Kenerley C.M., Horwitz B.A.;
RT "Secretome of Trichoderma interacting with maize roots: role in induced
RT systemic resistance.";
RL Mol. Cell. Proteomics 14:1054-1063(2015).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX DOI=10.1016/j.pmpp.2020.101476;
RA Muthukathan G., Mukherjee P., Salaskar D., Pachauri S., Tak H.,
RA Ganapathi T.R., Mukherjee P.K.;
RT "Secretome of Trichoderma virens induced by banana roots - identification
RT of novel fungal proteins for enhancing plant defence.";
RL Physiol. Mol. Plant Pathol. 110:101476-101476(2020).
RN [4] {ECO:0000305}
RP SUBUNIT.
RX PubMed=32510466; DOI=10.1107/s2053230x20007025;
RA Bansal R., Mistry H.U., Mukherjee P.K., Gupta G.D.;
RT "Expression, purification, crystallization and X-ray diffraction studies of
RT a novel root-induced secreted protein from Trichoderma virens.";
RL Acta Crystallogr. F Struct. Biol. Commun. 76:257-262(2020).
RN [5] {ECO:0007744|PDB:7CWJ, ECO:0007744|PDB:7CWP, ECO:0007744|PDB:7ESW}
RP X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 19-147, FUNCTION, SUBUNIT, AND
RP DISULFIDE BOND.
RX PubMed=34547313; DOI=10.1016/j.ijbiomac.2021.09.085;
RA Gupta G.D., Bansal R., Mistry H., Pandey B., Mukherjee P.K.;
RT "Structure-function analysis reveals Trichoderma virens Tsp1 to be a novel
RT fungal effector protein modulating plant defence.";
RL Int. J. Biol. Macromol. 191:267-276(2021).
CC -!- FUNCTION: Stimulates salicylic acid signaling in host plant roots.
CC {ECO:0000269|PubMed:34547313}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:32510466,
CC ECO:0000269|PubMed:34547313}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25681119,
CC ECO:0000269|Ref.3}.
CC -!- INDUCTION: Induced during growth on maize and banana roots.
CC {ECO:0000269|PubMed:25681119, ECO:0000269|Ref.3}.
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DR EMBL; ABDF02000005; EHK24054.1; -; Genomic_DNA.
DR RefSeq; XP_013958253.1; XM_014102778.1.
DR PDB; 7CWJ; X-ray; 1.61 A; A=19-147.
DR PDB; 7CWP; X-ray; 2.10 A; A=19-147.
DR PDB; 7ESW; X-ray; 1.25 A; A=19-147.
DR PDBsum; 7CWJ; -.
DR PDBsum; 7CWP; -.
DR PDBsum; 7ESW; -.
DR SMR; G9MQD3; -.
DR STRING; 413071.G9MQD3; -.
DR EnsemblFungi; EHK24054; EHK24054; TRIVIDRAFT_215947.
DR GeneID; 25791027; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_215947; -.
DR eggNOG; ENOG502SPD0; Eukaryota.
DR HOGENOM; CLU_117282_0_0_1; -.
DR InParanoid; G9MQD3; -.
DR OMA; TWTFGIY; -.
DR OrthoDB; 1444156at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0140404; P:effector-mediated modulation of host innate immune response by symbiont; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..147
FT /note="Effector TSP1"
FT /evidence="ECO:0000255"
FT /id="PRO_5003524114"
FT DISULFID 44..51
FT /evidence="ECO:0000269|PubMed:34547313,
FT ECO:0007744|PDB:7CWJ, ECO:0007744|PDB:7CWP,
FT ECO:0007744|PDB:7ESW"
FT DISULFID 67..87
FT /evidence="ECO:0000269|PubMed:34547313,
FT ECO:0007744|PDB:7CWJ, ECO:0007744|PDB:7ESW"
FT STRAND 35..44
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 48..58
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 65..72
FT /evidence="ECO:0007829|PDB:7ESW"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 82..87
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 90..97
FT /evidence="ECO:0007829|PDB:7ESW"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 106..113
FT /evidence="ECO:0007829|PDB:7ESW"
FT TURN 114..117
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 118..120
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 123..125
FT /evidence="ECO:0007829|PDB:7ESW"
FT HELIX 126..129
FT /evidence="ECO:0007829|PDB:7ESW"
FT HELIX 130..132
FT /evidence="ECO:0007829|PDB:7ESW"
FT STRAND 139..141
FT /evidence="ECO:0007829|PDB:7ESW"
SQ SEQUENCE 147 AA; 15393 MW; AD6C55B0FCCB446B CRC64;
MQITKTLVAT LFAASTAFAA PTPADKSMMA AVPEWTITNL KRVCNAGNTS CTWTFGVDTH
LATATSCTYV VKANANASQA SGGPVTCGPY TITSSWSGQF GPNNGFTTFA VTDFSKKLIV
WPAYTDVQVQ AGKVVSPNQS YAPANLP
