SSEC_SALTY
ID SSEC_SALTY Reviewed; 484 AA.
AC O84947; Q2I3D0; Q7CQL9; Q9R804;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Secreted effector protein SseC;
DE AltName: Full=Secretion system effector C;
GN Name=sseC; OrderedLocusNames=STM1400;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 14028 / SGSC 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=9786193; DOI=10.1046/j.1365-2958.1998.01047.x;
RA Hensel M., Shea J.E., Waterman S.R., Mundy R., Nikolaus T., Banks G.,
RA Vazquez-Torres A., Gleeson C., Fang F.C., Holden D.W.;
RT "Genes encoding putative effector proteins of the type III secretion system
RT of Salmonella pathogenicity island 2 are required for bacterial virulence
RT and proliferation in macrophages.";
RL Mol. Microbiol. 30:163-174(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SL1344;
RX PubMed=9786194; DOI=10.1046/j.1365-2958.1998.01048.x;
RA Cirillo D.M., Valdivia R.H., Monack D.M., Falkow S.;
RT "Macrophage-dependent induction of the Salmonella pathogenicity island 2
RT type III secretion system and its role in intracellular survival.";
RL Mol. Microbiol. 30:175-188(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-383.
RC STRAIN=S1605;
RX PubMed=16757591; DOI=10.1128/jcm.02630-05;
RA Tracz D.M., Tabor H., Jerome M., Ng L.K., Gilmour M.W.;
RT "Genetic determinants and polymorphisms specific for human-adapted serovars
RT of Salmonella enterica that cause enteric fever.";
RL J. Clin. Microbiol. 44:2007-2018(2006).
RN [5]
RP FUNCTION IN VIRULENCE, SUBCELLULAR LOCATION, AND SECRETION VIA TYPE III
RP SECRETION SYSTEM.
RC STRAIN=SL1344;
RX PubMed=11159962; DOI=10.1128/iai.69.2.737-743.2001;
RA Klein J.R., Jones B.D.;
RT "Salmonella pathogenicity island 2-encoded proteins SseC and SseD are
RT essential for virulence and are substrates of the type III secretion
RT system.";
RL Infect. Immun. 69:737-743(2001).
RN [6]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND SECRETION VIA TYPE III
RP SECRETION SYSTEM.
RC STRAIN=ATCC 14028 / SGSC 2980 / CDC 6516-60 / NCTC 12023;
RX PubMed=11567004; DOI=10.1128/jb.183.20.6036-6045.2001;
RA Nikolaus T., Deiwick J., Rappl C., Freeman J.A., Schroder W., Miller S.I.,
RA Hensel M.;
RT "SseBCD proteins are secreted by the type III secretion system of
RT Salmonella pathogenicity island 2 and function as a translocon.";
RL J. Bacteriol. 183:6036-6045(2001).
RN [7]
RP ROLE IN SPVB EXPORT, AND DISRUPTION PHENOTYPE.
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=18248436; DOI=10.1111/j.1574-695x.2007.00364.x;
RA Browne S.H., Hasegawa P., Okamoto S., Fierer J., Guiney D.G.;
RT "Identification of Salmonella SPI-2 secretion system components required
RT for SpvB-mediated cytotoxicity in macrophages and virulence in mice.";
RL FEMS Immunol. Med. Microbiol. 52:194-201(2008).
CC -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC promote bacterial survival in host tissues. May act as a translocator
CC that mediates translocation of SPI-2 TTSS effector proteins from
CC intraphagosomal bacterial cells into the host cells.
CC {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004,
CC ECO:0000269|PubMed:18248436}.
CC -!- SUBUNIT: May form a complex with SseB and SseD. SseB is required for
CC correct localization of SseC on the bacterial cell surface.
CC {ECO:0000269|PubMed:11567004}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11159962,
CC ECO:0000269|PubMed:11567004}. Cell surface
CC {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}.
CC Note=Secreted via type III secretion system 2 (SPI-2 TTSS). After
CC secretion, localizes mainly on the surface of the bacterial cell.
CC {ECO:0000269|PubMed:11159962, ECO:0000269|PubMed:11567004}.
CC -!- DISRUPTION PHENOTYPE: Mutant is severely attenuated in virulence.
CC Disruption prevents SpvB-induced F-actin depolymerization in human
CC macrophages without affecting intra-bacterial SpvB protein levels.
CC {ECO:0000269|PubMed:18248436, ECO:0000269|PubMed:9786193}.
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DR EMBL; AJ224892; CAA12187.1; -; Genomic_DNA.
DR EMBL; AF020808; AAC28881.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20324.1; -; Genomic_DNA.
DR EMBL; DQ320510; ABC59204.1; -; Genomic_DNA.
DR RefSeq; NP_460365.1; NC_003197.2.
DR RefSeq; WP_001079760.1; NC_003197.2.
DR AlphaFoldDB; O84947; -.
DR SMR; O84947; -.
DR STRING; 99287.STM1400; -.
DR TCDB; 1.C.36.5.1; the bacterial type iii-target cell pore (iiitcp) family.
DR PaxDb; O84947; -.
DR EnsemblBacteria; AAL20324; AAL20324; STM1400.
DR GeneID; 1252918; -.
DR KEGG; stm:STM1400; -.
DR PATRIC; fig|99287.12.peg.1484; -.
DR HOGENOM; CLU_042650_0_0_6; -.
DR OMA; QARIAGC; -.
DR BioCyc; SENT99287:STM1400-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR GO; GO:0005576; C:extracellular region; IDA:AgBase.
DR GO; GO:0051087; F:chaperone binding; IPI:AgBase.
DR GO; GO:0030254; P:protein secretion by the type III secretion system; IDA:UniProtKB.
DR InterPro; IPR006972; SseC.
DR Pfam; PF04888; SseC; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Protein transport; Reference proteome; Secreted; Transport;
KW Virulence.
FT CHAIN 1..484
FT /note="Secreted effector protein SseC"
FT /id="PRO_0000391716"
FT COILED 107..152
FT /evidence="ECO:0000255"
FT COILED 413..457
FT /evidence="ECO:0000255"
FT CONFLICT 458
FT /note="S -> T (in Ref. 1; CAA12187)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 484 AA; 52777 MW; 14C40E43A0699285 CRC64;
MNRIHSNSDS AAGVTALTHH HLSNVSCVSS GSLGKRQHRV NSTFGDGNAA CLLSGKISLQ
EASNALKQLL DAVPGNHKRP SLPDFLQTNP AVLSMMMTSL ILNVFGNNAQ SLCQQLERAT
EVQNALRNKQ VKEYQEQIQK AIEQEDKARK AGIFGAIFDW ITGIFETVIG ALKVVEGFLS
GNPAEMASGV AYMAAGCAGM VKAGAETAMM CGADHDTCQA IIDVTSKIQF GCEAVALALD
VFQIGRAFMA TRGLSGAAAK VLDSGFGEEV VERMVGAGEA EIEELAEKFG EEVSESFSKQ
FEPLEREMAM ANEMAEEAAE FSRNVENNMT RSAGKSFTKE GVKAMAKEAA KEALEKCVQE
GGKFLLKKFR NKVLFNMFKK ILYALLRDCS FKGLQAIRCA TEGASQMNTG MVNTEKAKIE
KKIEQLITQQ RFLDFIMQQT ENQKKIEQKR LEELYKGSGA ALRDVLDTID HYSSVQARIA
GYRA
