SSEL_SALTI
ID SSEL_SALTI Reviewed; 340 AA.
AC Q8Z550; Q83T72;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Deubiquitinase SseL;
DE EC=3.4.22.-;
DE AltName: Full=Deubiquitinating enzyme;
DE Short=DUB;
DE AltName: Full=Deubiquitinating protease;
DE AltName: Full=Salmonella secreted effector L;
GN Name=sseL; OrderedLocusNames=STY2517, t0576;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC promote bacterial survival in host tissues. This protease targets the
CC host cell ubiquitin pathway by acting as a deubiquitinase in infected
CC host cells (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cytoplasm
CC {ECO:0000250}. Note=Secreted via type III secretion system 2 (SPI-2
CC TTSS), and delivered into the host cytoplasm. In phagocytic cells
CC localizes to the Salmonella-containing vacuole (SCV). In epithelial
CC cells localizes to the Salmonella-containing vacuole (SCV) and to the
CC Salmonella-induced filaments (Sifs), which are tubular membrane
CC extensions from the SCV that are formed at late stages of infection (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C79 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO68282.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD07520.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL513382; CAD07520.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014613; AAO68282.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_456831.1; NC_003198.1.
DR RefSeq; WP_001017745.1; NZ_CJUM01000015.1.
DR AlphaFoldDB; Q8Z550; -.
DR SMR; Q8Z550; -.
DR STRING; 220341.16503513; -.
DR EnsemblBacteria; AAO68282; AAO68282; t0576.
DR KEGG; stt:t0576; -.
DR KEGG; sty:STY2517; -.
DR PATRIC; fig|220341.7.peg.2548; -.
DR eggNOG; COG5160; Bacteria.
DR HOGENOM; CLU_069513_0_0_6; -.
DR OMA; YRLSTPQ; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Host cytoplasm; Hydrolase; Protease; Secreted; Thiol protease; Virulence.
FT CHAIN 1..340
FT /note="Deubiquitinase SseL"
FT /id="PRO_0000323574"
FT ACT_SITE 223
FT /evidence="ECO:0000250"
FT ACT_SITE 285
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT CONFLICT 262
FT /note="T -> A (in Ref. 2; AAO68282)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 38314 MW; AE0FDA328C26504F CRC64;
MNICVNSLYR LSTPQFHSLY SEEVSDEALA LLFSAVENGD QNCIDLLCNL ALRNDNLGHR
VEKFLFDLFS GKRSGSPDID KKINQACLVL HQIANNDITK DNTEWKKLHA PSRLLYMAGS
ATTDLSKKIG IAHKIMGDQF AQTDQEQVGV ENLWCSARML SSDELAAATL GLVQESPLLS
VNYPIGLIHP TTKENILRTQ LLEKMAQSGL SENEVFLINT GDHWLICLFY KLAEKIKCLI
FNTYHDLNEN TKQEIIEAAK ITGISENEDI DFIETNLQNN VPNGCGLFCY HTIQLLSNAG
QNDPATTLRE FAENFLTLSV EEQTLFNTQT RRQIYEYSLQ
