SSF1_MOUSE
ID SSF1_MOUSE Reviewed; 470 AA.
AC Q91YU8; Q8BYM4;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Suppressor of SWI4 1 homolog;
DE Short=Ssf-1;
DE AltName: Full=Peter Pan homolog;
GN Name=Ppan; Synonyms=Ssf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238; SER-240 AND SER-362, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-441, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: May have a role in cell growth. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR EMBL; AK039027; BAC30210.1; -; mRNA.
DR EMBL; CH466522; EDL25137.1; -; Genomic_DNA.
DR EMBL; BC014688; AAH14688.1; -; mRNA.
DR CCDS; CCDS22887.1; -.
DR RefSeq; NP_663585.2; NM_145610.2.
DR AlphaFoldDB; Q91YU8; -.
DR SMR; Q91YU8; -.
DR BioGRID; 231610; 5.
DR STRING; 10090.ENSMUSP00000004203; -.
DR iPTMnet; Q91YU8; -.
DR PhosphoSitePlus; Q91YU8; -.
DR EPD; Q91YU8; -.
DR jPOST; Q91YU8; -.
DR MaxQB; Q91YU8; -.
DR PaxDb; Q91YU8; -.
DR PeptideAtlas; Q91YU8; -.
DR PRIDE; Q91YU8; -.
DR ProteomicsDB; 258736; -.
DR DNASU; 235036; -.
DR Ensembl; ENSMUST00000004203; ENSMUSP00000004203; ENSMUSG00000004100.
DR GeneID; 235036; -.
DR KEGG; mmu:235036; -.
DR UCSC; uc009ojk.2; mouse.
DR CTD; 56342; -.
DR MGI; MGI:2178445; Ppan.
DR VEuPathDB; HostDB:ENSMUSG00000004100; -.
DR eggNOG; KOG2963; Eukaryota.
DR GeneTree; ENSGT00530000064158; -.
DR HOGENOM; CLU_026936_0_1_1; -.
DR InParanoid; Q91YU8; -.
DR OMA; MWHEYIH; -.
DR OrthoDB; 1199197at2759; -.
DR PhylomeDB; Q91YU8; -.
DR TreeFam; TF318923; -.
DR BioGRID-ORCS; 235036; 27 hits in 69 CRISPR screens.
DR ChiTaRS; Ppan; mouse.
DR PRO; PR:Q91YU8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91YU8; protein.
DR Bgee; ENSMUSG00000004100; Expressed in yolk sac and 67 other tissues.
DR ExpressionAtlas; Q91YU8; baseline and differential.
DR Genevisible; Q91YU8; MM.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0001560; P:regulation of cell growth by extracellular stimulus; ISO:MGI.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR InterPro; IPR007109; Brix.
DR InterPro; IPR045112; PPAN-like.
DR PANTHER; PTHR12661; PTHR12661; 1.
DR Pfam; PF04427; Brix; 1.
DR SMART; SM00879; Brix; 1.
DR PROSITE; PS50833; BRIX; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..470
FT /note="Suppressor of SWI4 1 homolog"
FT /id="PRO_0000120258"
FT DOMAIN 29..292
FT /note="Brix"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT REGION 240..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 240
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 362
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 441
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 411
FT /note="Q -> P (in Ref. 3; AAH14688)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 470 AA; 52756 MW; 2255C919FBAE67C3 CRC64;
MGQSGRSRHQ KRNRAQAQLR NLESYAAQPH SFVFTRGRAG RNVRQLSLDV RRVMEPLTAT
RLQVRKKNSL KDCVAVAGPL GVTHFLILTK TDNSVYLKLM RLPGGPTLTF QISKYTLIRD
VVSSLRRHRM HEQQFNHPPL LVLNSFGPQG MHIKLMATMF QNLFPSINVH TVNLNTIKRC
LLINYNPDSQ ELDFRHYSVK VVPVGASRGM KKLLQEKFPN MSRLQDISEL LATGVGLSDS
EVEPDGEHNT TELPQAVAGR GNMQAQQSAV RLTEIGPRMT LQLIKIQEGV GNGNVLFHSF
VHKTEEELQA ILAAKEEKLR LKAQRQNQQA ENLQRKQELR EAHKKKSLAG IKRARARADG
DSDAEDPGAP PEAVGAGQPE DEEDDAEYFR QAVGEEPDED LFPTAAKRRR QGGPLGKKQR
GKEQRPGNKG RGQGGNWQAL KLQGRSQRGK AKPRPRATHQ DSRPASRRRN
