ID   ABHD_DICDI              Reviewed;         395 AA.
AC   Q54H38;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Abhydrolase domain-containing protein;
DE            EC=3.1.1.-;
GN   Name=abhd; ORFNames=DDB_G0289723;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000148; EAL62573.1; -; Genomic_DNA.
DR   RefSeq; XP_636080.1; XM_630988.1.
DR   AlphaFoldDB; Q54H38; -.
DR   STRING; 44689.DDB0237966; -.
DR   ESTHER; dicdi-abhd; abh_upf0017.
DR   PaxDb; Q54H38; -.
DR   EnsemblProtists; EAL62573; EAL62573; DDB_G0289723.
DR   GeneID; 8627292; -.
DR   KEGG; ddi:DDB_G0289723; -.
DR   dictyBase; DDB_G0289723; abhd.
DR   eggNOG; KOG1838; Eukaryota.
DR   HOGENOM; CLU_032487_1_1_1; -.
DR   InParanoid; Q54H38; -.
DR   OMA; DHCRRFY; -.
DR   PhylomeDB; Q54H38; -.
DR   Reactome; R-DDI-1483191; Synthesis of PC.
DR   PRO; PR:Q54H38; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0008126; F:acetylesterase activity; IBA:GO_Central.
DR   GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR   GO; GO:0034338; F:short-chain carboxylesterase activity; IBA:GO_Central.
DR   GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR   GO; GO:0051792; P:medium-chain fatty acid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0051793; P:medium-chain fatty acid catabolic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR012020; ABHD4.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF005211; Ab_hydro_YheT; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..395
FT                   /note="Abhydrolase domain-containing protein"
FT                   /id="PRO_0000344505"
FT   DOMAIN          117..331
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        200
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        327
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        356
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   395 AA;  45168 MW;  228ED9FB2F1D1381 CRC64;
     MFSSRDKAEV KLYFDSNNEE NQKILDQCPH LYQKYDKDVT INDRINNIED SEPTIKNGVT
     FYPPYYLYNS HFMNYYGSYK IPKLNLKTRR EILVNPIDGG TISLDFFELG EFKEDTPTIV
     INHGLTGGSH ERYVQYFAQR AYKEKGFRSV VFNYRGCAGN PITADRAYSA VQLDDIKFVT
     EYLTKTALPL VKKWFLVGFS LGSAILVNYM ADAGKDSPYL AHVSISNPMN MVECTKNLSS
     TYINNLIYNK GLANNLKRLF RKFDGRLDKY ATKEQIMAAQ TIADFDDLIT SKMFGFETAH
     DYYLAASSSK SIRNLVKPIL FINAIDDPIA PTSGFPWKDF KSNPNTILCV SRWGGHLGFI
     SYEDHMSWSD KAAVEYLSTF LDDNNNNNDN DNKTE