ID   SSGB_SACEN              Reviewed;         141 AA.
AC   A4FB46;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Sporulation-specific cell division protein SsgB {ECO:0000303|PubMed:19567872};
DE   AltName: Full=Sporulation of Streptomyces griseus-like protein B {ECO:0000303|PubMed:19567872};
DE   AltName: Full=SsgA-like protein B {ECO:0000303|PubMed:19567872};
DE            Short=SALP B {ECO:0000303|PubMed:19567872};
GN   Name=ssgB {ECO:0000303|PubMed:19567872};
GN   OrderedLocusNames=SACE_1961 {ECO:0000312|EMBL:CAM01271.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000312|EMBL:CAM01271.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338 {ECO:0000303|PubMed:19567872};
RX   PubMed=19567872; DOI=10.1074/jbc.m109.018564;
RA   Xu Q., Traag B.A., Willemse J., McMullan D., Miller M.D., Elsliger M.A.,
RA   Abdubek P., Astakhova T., Axelrod H.L., Bakolitsa C., Carlton D., Chen C.,
RA   Chiu H.J., Chruszcz M., Clayton T., Das D., Deller M.C., Duan L.,
RA   Ellrott K., Ernst D., Farr C.L., Feuerhelm J., Grant J.C., Grzechnik A.,
RA   Grzechnik S.K., Han G.W., Jaroszewski L., Jin K.K., Klock H.E., Knuth M.W.,
RA   Kozbial P., Krishna S.S., Kumar A., Marciano D., Minor W., Mommaas A.M.,
RA   Morse A.T., Nigoghossian E., Nopakun A., Okach L., Oommachen S.,
RA   Paulsen J., Puckett C., Reyes R., Rife C.L., Sefcovic N., Tien H.J.,
RA   Trame C.B., van den Bedem H., Wang S., Weekes D., Hodgson K.O., Wooley J.,
RA   Deacon A.M., Godzik A., Lesley S.A., Wilson I.A., van Wezel G.P.;
RT   "Structural and functional characterizations of SsgB, a conserved activator
RT   of developmental cell division in morphologically complex actinomycetes.";
RL   J. Biol. Chem. 284:25268-25279(2009).
RN   [2] {ECO:0000312|EMBL:CAM01271.1, ECO:0000312|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338 {ECO:0000312|Proteomes:UP000006728};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: Involved in sporulation-specific cell division
CC       (PubMed:19567872). Required for early stages of sporulation. Important
CC       in the process of growth cessation prior to sporulation-specific cell
CC       division. Recruits cell division protein FtsZ to the future septum
CC       sites and tethers the contractile ring structure (Z ring) to the
CC       cytoplasmic membrane during sporulation. Stimulates polymerization and
CC       filament length of FtsZ in vitro (By similarity).
CC       {ECO:0000250|UniProtKB:Q47N25, ECO:0000250|UniProtKB:Q9L268,
CC       ECO:0000269|PubMed:19567872}.
CC   -!- SUBUNIT: Interacts with SsgA. Interacts with FtsZ (via N-terminus).
CC       {ECO:0000250|UniProtKB:Q47N25, ECO:0000250|UniProtKB:Q9L268}.
CC   -!- SUBCELLULAR LOCATION: Cell septum {ECO:0000250|UniProtKB:Q9L268}.
CC       Note=Localizes to the divisome in sporogenic aerial hyphae in a ladder-
CC       like manner. Temporospatial localization is controlled by SsgA and it
CC       colocalizes with SsgA in presporulation foci. Localizes to the septum
CC       sites prior to FtsZ and after that colocalizes with FtsZ at the
CC       divisome throughout cell division. {ECO:0000250|UniProtKB:Q9L268}.
CC   -!- SIMILARITY: Belongs to the SsgA family. {ECO:0000305}.
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DR   EMBL; AM420293; CAM01271.1; -; Genomic_DNA.
DR   RefSeq; WP_011873518.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FB46; -.
DR   SMR; A4FB46; -.
DR   STRING; 405948.SACE_1961; -.
DR   EnsemblBacteria; CAM01271; CAM01271; SACE_1961.
DR   KEGG; sen:SACE_1961; -.
DR   eggNOG; ENOG5032RFA; Bacteria.
DR   HOGENOM; CLU_126599_0_1_11; -.
DR   OMA; NDEPVEW; -.
DR   OrthoDB; 1627707at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.31.20; -; 1.
DR   InterPro; IPR006776; SsgB.
DR   InterPro; IPR038658; SsgB_sf.
DR   Pfam; PF04686; SsgA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Reference proteome; Septation;
KW   Sporulation.
FT   CHAIN           1..141
FT                   /note="Sporulation-specific cell division protein SsgB"
FT                   /id="PRO_0000435312"
SQ   SEQUENCE   141 AA;  15446 MW;  4EE4D0F724EAF8AC CRC64;
     MRNDHVTLRS TAVFDLLAPQ TPAVPVQVEL RYDTRDPYAV VAAFRTGRAG WVEWVFARDL
     LADGLIAHAG VGDVTIRPAV DDPEVVVIEL SSPSGHAVFE ASAQELADFL DRTYDVVVPG
     NENLWVNVDD ALTRLLPHDL S