ID   SSI15_STRBI             Reviewed;         113 AA.
AC   Q9R645;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Subtilisin inhibitor-like protein 15;
DE            Short=SIL-15;
DE            Short=SIL15;
OS   Streptomyces bikiniensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1896;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RX   PubMed=7629030; DOI=10.1093/oxfordjournals.jbchem.a124752;
RA   Terabe M., Kojima S., Taguchi S., Momose H., Miura K.;
RT   "A subtilisin inhibitor produced by Streptomyces bikiniensis possesses a
RT   glutamine residue at reactive site P1.";
RL   J. Biochem. 117:609-613(1995).
CC   -!- FUNCTION: Inhibitor of subtilisin BPN'.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I16 (SSI) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; Q9R645; -.
DR   SMR; Q9R645; -.
DR   MEROPS; I16.016; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.350.10; -; 1.
DR   HAMAP; MF_00778; SSI; 1.
DR   InterPro; IPR000691; Prot_inh_I16_SSI.
DR   InterPro; IPR020054; Prot_inh_SSI_I16_CS.
DR   InterPro; IPR023549; Subtilisin_inhibitor.
DR   InterPro; IPR036819; Subtilisin_inhibitor-like_sf.
DR   Pfam; PF00720; SSI; 1.
DR   PRINTS; PR00294; SSBTLNINHBTR.
DR   SUPFAM; SSF55399; SSF55399; 1.
DR   PROSITE; PS00999; SSI; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..113
FT                   /note="Subtilisin inhibitor-like protein 15"
FT                   /id="PRO_0000208657"
FT   SITE            73..74
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..101
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  11300 MW;  5FB3DC1A179B5787 CRC64;
     SLYAPSAVVL SIGKGDASGP VTVLRATTLS CAPVPGGTHP APEAACAELK AGFAGGGFGG
     LLASPDPDRA CPQHFDPVTV TLDGVWEGAR TSWQHTFSNA CVMGTTLDGG EAF