ID   SSI_STRAN               Reviewed;         109 AA.
AC   P01007;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Plasminostreptin;
DE            Short=PSN;
OS   Streptomyces antifibrinolyticus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1891;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=627554; DOI=10.1016/s0021-9258(17)34900-1;
RA   Sugino H., Kakinuma A., Iwanaga S.;
RT   "Plasminostreptin, a protein proteinase inhibitor produced by Streptomyces
RT   antifibrinolyticus. III. Elucidation of the primary structure.";
RL   J. Biol. Chem. 253:1546-1555(1978).
CC   -!- FUNCTION: Inhibits plasmin, trypsin, subtilisin, and other microbial
CC       alkaline proteases.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I16 (SSI) family.
CC       {ECO:0000305}.
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DR   PIR; A01241; XFSMF.
DR   AlphaFoldDB; P01007; -.
DR   SMR; P01007; -.
DR   MEROPS; I16.001; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.350.10; -; 1.
DR   HAMAP; MF_00778; SSI; 1.
DR   InterPro; IPR000691; Prot_inh_I16_SSI.
DR   InterPro; IPR020054; Prot_inh_SSI_I16_CS.
DR   InterPro; IPR023549; Subtilisin_inhibitor.
DR   InterPro; IPR036819; Subtilisin_inhibitor-like_sf.
DR   Pfam; PF00720; SSI; 1.
DR   PRINTS; PR00294; SSBTLNINHBTR.
DR   SUPFAM; SSF55399; SSF55399; 1.
DR   PROSITE; PS00999; SSI; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..109
FT                   /note="Plasminostreptin"
FT                   /id="PRO_0000208656"
FT   SITE            69..70
FT                   /note="Reactive bond"
FT   DISULFID        31..46
FT   DISULFID        67..97
SQ   SEQUENCE   109 AA;  11399 MW;  DFBC5F29A96C50EF CRC64;
     GLYAPSALVL TMGHGNSAAT VNPERAVTLN CAPTASGTHP AALQACAELR GAGGDFDALT
     VRGDVACTKQ FDPVVVTVDG VWQGKRVSYE RTFANECVKN SYGMTVFTF