ID   SSI_STRNE               Reviewed;         110 AA.
AC   P80596; P80599;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Protease inhibitor SIL-V1/SIL-V4;
OS   Streptomyces netropsis (Streptoverticillium netropsis).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=55404;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=ATCC 23940 / DSM 40259 / JCM 4655 / NBRC 12893 / NRRL B-2268 / ISP
RC   5259, and ISP 5093;
RX   PubMed=9115178; DOI=10.1007/pl00006178;
RA   Taguchi S., Kojima S., Terabe M., Kumazawa Y., Kohriyama H., Suzuki M.,
RA   Miura K., Momose H.;
RT   "Molecular phylogenetic characterization of Streptomyces protease inhibitor
RT   family.";
RL   J. Mol. Evol. 44:542-551(1997).
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I16 (SSI) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P80596; -.
DR   SMR; P80596; -.
DR   MEROPS; I16.016; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.350.10; -; 1.
DR   HAMAP; MF_00778; SSI; 1.
DR   InterPro; IPR000691; Prot_inh_I16_SSI.
DR   InterPro; IPR020054; Prot_inh_SSI_I16_CS.
DR   InterPro; IPR023549; Subtilisin_inhibitor.
DR   InterPro; IPR036819; Subtilisin_inhibitor-like_sf.
DR   Pfam; PF00720; SSI; 1.
DR   PRINTS; PR00294; SSBTLNINHBTR.
DR   SUPFAM; SSF55399; SSF55399; 1.
DR   PROSITE; PS00999; SSI; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..110
FT                   /note="Protease inhibitor SIL-V1/SIL-V4"
FT                   /id="PRO_0000208667"
FT   SITE            70..71
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..46
FT                   /evidence="ECO:0000250"
FT   DISULFID        68..98
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   110 AA;  11645 MW;  E5B6765379570D40 CRC64;
     SLFAPSALVL TVGEGESAAD SGVQRAVTLT CTPKASGTHP AARAACDQLR AVDGDFKALV
     TTKSDRVCTK EYRPIVITAE GVWDGHRVSY EHKFANPCMA SDGKGVVFEF