ID   SSK_BOMMO               Reviewed;         157 AA.
AC   H9JBU5;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 2.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Protein snakeskin {ECO:0000250|UniProtKB:Q9VW87};
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091 {ECO:0000312|Proteomes:UP000005204};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-27, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RC   TISSUE=Midgut {ECO:0000303|PubMed:22328496};
RX   PubMed=22328496; DOI=10.1242/jcs.096800;
RA   Yanagihashi Y., Usui T., Izumi Y., Yonemura S., Sumida M., Tsukita S.,
RA   Uemura T., Furuse M.;
RT   "Snakeskin, a membrane protein associated with smooth septate junctions, is
RT   required for intestinal barrier function in Drosophila.";
RL   J. Cell Sci. 125:1980-1990(2012).
RN   [2] {ECO:0000312|Proteomes:UP000005204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=p50T {ECO:0000312|Proteomes:UP000005204};
RX   PubMed=15591204; DOI=10.1126/science.1102210;
RA   Xia Q., Zhou Z., Lu C., Cheng D., Dai F., Li B., Zhao P., Zha X., Cheng T.,
RA   Chai C., Pan G., Xu J., Liu C., Lin Y., Qian J., Hou Y., Wu Z., Li G.,
RA   Pan M., Li C., Shen Y., Lan X., Yuan L., Li T., Xu H., Yang G., Wan Y.,
RA   Zhu Y., Yu M., Shen W., Wu D., Xiang Z., Yu J., Wang J., Li R., Shi J.,
RA   Li H., Li G., Su J., Wang X., Li G., Zhang Z., Wu Q., Li J., Zhang Q.,
RA   Wei N., Xu J., Sun H., Dong L., Liu D., Zhao S., Zhao X., Meng Q., Lan F.,
RA   Huang X., Li Y., Fang L., Li C., Li D., Sun Y., Zhang Z., Yang Z.,
RA   Huang Y., Xi Y., Qi Q., He D., Huang H., Zhang X., Wang Z., Li W., Cao Y.,
RA   Yu Y., Yu H., Li J., Ye J., Chen H., Zhou Y., Liu B., Wang J., Ye J.,
RA   Ji H., Li S., Ni P., Zhang J., Zhang Y., Zheng H., Mao B., Wang W., Ye C.,
RA   Li S., Wang J., Wong G.K.-S., Yang H.;
RT   "A draft sequence for the genome of the domesticated silkworm (Bombyx
RT   mori).";
RL   Science 306:1937-1940(2004).
CC   -!- FUNCTION: Required for assembly of smooth septate junctions (sSJs). May
CC       be important for barrier function of the midgut epithelium.
CC       {ECO:0000250|UniProtKB:Q9VW87}.
CC   -!- SUBCELLULAR LOCATION: Apicolateral cell membrane
CC       {ECO:0000269|PubMed:22328496}; Multi-pass membrane protein
CC       {ECO:0000255}. Cell junction, septate junction
CC       {ECO:0000250|UniProtKB:Q9VW87}. Note=Specific to smooth septate
CC       junctions. {ECO:0000250|UniProtKB:Q9VW87}.
CC   -!- TISSUE SPECIFICITY: Expressed in midgut epithelium (at protein level).
CC       {ECO:0000269|PubMed:22328496}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BABH01015024; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; BABH01015024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H9JBU5; -.
DR   STRING; 7091.BGIBMGA006990-TA; -.
DR   eggNOG; ENOG502RZZJ; Eukaryota.
DR   HOGENOM; CLU_130085_0_0_1; -.
DR   InParanoid; H9JBU5; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0016327; C:apicolateral plasma membrane; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005918; C:septate junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0019991; P:septate junction assembly; IEA:InterPro.
DR   InterPro; IPR038976; Ssk.
DR   PANTHER; PTHR36692; PTHR36692; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Direct protein sequencing; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:22328496"
FT   CHAIN           2..157
FT                   /note="Protein snakeskin"
FT                   /id="PRO_0000437456"
FT   TOPO_DOM        2..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VW87"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..53
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VW87"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..87
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VW87"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..130
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VW87"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..157
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VW87"
SQ   SEQUENCE   157 AA;  17289 MW;  0D3A5A13ED4FE87D CRC64;
     MVSVQTIATI VVKTFKIVLN IIILVLYRTG YNGEFLGVGG TWNLNEEKNP DAEIVASGVI
     VGYLIYTLVQ IVTFLFGTTE HKRALSEIVM NFVGVFLWIA VGAVALHYWG GYQGEHQFQF
     VFAEKQVGLA VGALCVINGA IYLLDTALSV IHFTKEM