ID   SSL10_STAAE             Reviewed;         227 AA.
AC   A0A0H3K6Z9;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Staphylococcal superantigen-like 10 {ECO:0000250|UniProtKB:Q2G2X7};
DE   Flags: Precursor;
GN   Name=ssl10 {ECO:0000250|UniProtKB:Q2G2X7}; OrderedLocusNames=NWMN_0397;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: Plays a role in the inhibition of host complement activation
CC       via the classical pathway by interacting with the Fc region of human
CC       IgG and thereby interfering with the IgG/C1q interaction. Inhibits also
CC       the penultimate step of plasma clotting by interacting with
CC       prothrombin/F2 and coagulation factor X/F12. Does not affect the
CC       protease activity of thrombin but interferes with the conversion of
CC       prothrombin to thrombin. Interacts with human receptor CXCR4 and
CC       specifically inhibits CXCL12-induced calcium mobilization and cell
CC       migration. {ECO:0000250|UniProtKB:Q2G2X7}.
CC   -!- SUBUNIT: Interacts with prothrombin/F2 and coagulation factor X/F12.
CC       Interacts with human CXCR4. {ECO:0000250|UniProtKB:Q2G2X7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2G1S8}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AP009351; BAF66669.1; -; Genomic_DNA.
DR   RefSeq; WP_000673051.1; NZ_CP023390.1.
DR   AlphaFoldDB; A0A0H3K6Z9; -.
DR   SMR; A0A0H3K6Z9; -.
DR   EnsemblBacteria; BAF66669; BAF66669; NWMN_0397.
DR   KEGG; sae:NWMN_0397; -.
DR   HOGENOM; CLU_054950_1_0_9; -.
DR   OMA; NINALKH; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR015282; SSL_OB.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR008375; Staph_exotoxin.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   InterPro; IPR006123; Toxin_b-grasp_Staph/Strep.
DR   Pfam; PF09199; SSL_OB; 1.
DR   Pfam; PF02876; Stap_Strp_tox_C; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   PRINTS; PR01800; STAPHEXOTOXN.
DR   PRINTS; PR01501; TOXICSSTOXIN.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   3: Inferred from homology;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..227
FT                   /note="Staphylococcal superantigen-like 10"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5002613488"
SQ   SEQUENCE   227 AA;  26111 MW;  732955609D2333DD CRC64;
     MKFTALAKAT LALGILTTGT LTTEVHSGHA KQNQKSVNKH DKEALYRYYT GKTMEMKNIS
     ALKHGKNNLR FKFRGIKIQV LLPGNDKSKF QQRSYEGLDV FFVQEKRDKH DIFYTVGGVI
     QNNKTSGVVS APILNISKEK GEDAFVKGYP YYIKKEKITL KELDYKLRKH LIEKYGLYKT
     ISKDGRVKIS LKDGSFYNLD LRSKLKFKYM GEVIESKQIK DIEVNLK