ID   SSL13_STAAE             Reviewed;         241 AA.
AC   A0A0H3K7M3;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Superantigen-like protein 13 {ECO:0000303|PubMed:30098280};
DE   Flags: Precursor;
GN   Name=ssl13 {ECO:0000303|PubMed:30098280}; OrderedLocusNames=NWMN_1076;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH HOST FPR2.
RX   PubMed=30098280; DOI=10.1111/cmi.12941;
RA   Zhao Y., van Kessel K.P.M., de Haas C.J.C., Rogers M.R.C.,
RA   van Strijp J.A.G., Haas P.A.;
RT   "Staphylococcal superantigen-like protein 13 activates neutrophils via
RT   formyl peptide receptor 2.";
RL   Cell. Microbiol. 20:E12941-E12941(2018).
CC   -!- FUNCTION: Acts as a pathogen alarming molecule by acting on host
CC       neutrophil chemotactic factors FPR2. Plays a role of chemoattractant
CC       and induces degranulation and oxidative burst in neutrophils.
CC       {ECO:0000269|PubMed:30098280}.
CC   -!- SUBUNIT: Interacts with host FPR2; this interaction promotes neutrophil
CC       chemotaxis. {ECO:0000269|PubMed:30098280}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AP009351; BAF67348.1; -; Genomic_DNA.
DR   RefSeq; WP_001063559.1; NZ_CP023390.1.
DR   AlphaFoldDB; A0A0H3K7M3; -.
DR   SMR; A0A0H3K7M3; -.
DR   EnsemblBacteria; BAF67348; BAF67348; NWMN_1076.
DR   KEGG; sae:NWMN_1076; -.
DR   HOGENOM; CLU_100596_0_0_9; -.
DR   OMA; EVDFRIR; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR008375; Staph_exotoxin.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   PRINTS; PR01800; STAPHEXOTOXN.
DR   PRINTS; PR01501; TOXICSSTOXIN.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..241
FT                   /note="Superantigen-like protein 13"
FT                   /id="PRO_5002613268"
SQ   SEQUENCE   241 AA;  27365 MW;  B9C6CE77DF4A7E7F CRC64;
     MNNNITKKII LSTTLLLLGT ASTQFPNTPI NSSSEAKAYY INQNETNVNE LTKYYSQKYL
     TFSNSTLWQK DNGTIHATLL QFSWYSHIQV YGPESWGNIN QLRNKSVDIF GIKDQETIDS
     FALSQETFTG GVTPAATSND KHYKLNVTYK DKAETFTGGF PVYEGNKPVL TLKELDFRIR
     QTLIKSKKLY NNSYNKGQIK ITGADNNYTI DLSKRLPSTD ANRYVKKPQN AKIEVILEKS
     N