ID   SSL1_STAA8              Reviewed;         226 AA.
AC   Q2G0X9;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Staphylococcal superantigen-like 1;
DE            EC=3.4.21.- {ECO:0000250|UniProtKB:A0A0H3KAV3};
DE   Flags: Precursor;
GN   Name=ssl1 {ECO:0000250|UniProtKB:A0A0H3KAV3};
GN   OrderedLocusNames=SAOUHSC_00383;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 26-226.
RA   Dutta D., Dutta A., Basak A., Das A.K.;
RT   "Crystal structure of Staphylococcal superantigen-like protein
RT   SAOUHSC_00383.";
RL   Submitted (DEC-2013) to the PDB data bank.
CC   -!- FUNCTION: Mediates virulence by proteolytically cleaving host proteins,
CC       including collagens types I and IV as well as human cytokines IL8,
CC       IL17A, and IFN-gamma. {ECO:0000250|UniProtKB:A0A0H3KAV3}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:A0A0H3KAV3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2G1S8}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; CP000253; ABD29548.1; -; Genomic_DNA.
DR   RefSeq; WP_000669005.1; NZ_LS483365.1.
DR   RefSeq; YP_498971.1; NC_007795.1.
DR   PDB; 4O1N; X-ray; 2.50 A; A/B/C/D/E/F=26-226.
DR   PDBsum; 4O1N; -.
DR   AlphaFoldDB; Q2G0X9; -.
DR   SMR; Q2G0X9; -.
DR   STRING; 1280.SAXN108_0476; -.
DR   EnsemblBacteria; ABD29548; ABD29548; SAOUHSC_00383.
DR   GeneID; 3919120; -.
DR   KEGG; sao:SAOUHSC_00383; -.
DR   PATRIC; fig|93061.5.peg.353; -.
DR   eggNOG; ENOG503054K; Bacteria.
DR   HOGENOM; CLU_054950_1_0_9; -.
DR   OMA; HIGANIM; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR015282; SSL_OB.
DR   InterPro; IPR008375; Staph_exotoxin.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   Pfam; PF09199; SSL_OB; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   PRINTS; PR01800; STAPHEXOTOXN.
DR   PRINTS; PR01501; TOXICSSTOXIN.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Protease; Reference proteome; Secreted; Signal;
KW   Virulence.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..226
FT                   /note="Staphylococcal superantigen-like 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004207693"
FT   HELIX           39..46
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          51..63
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          66..73
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          76..81
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   HELIX           86..89
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          92..102
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          111..116
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          119..121
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          135..140
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          143..149
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          155..158
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   HELIX           159..174
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          186..190
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          195..198
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   HELIX           206..208
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          212..214
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   HELIX           215..217
FT                   /evidence="ECO:0007829|PDB:4O1N"
FT   STRAND          218..225
FT                   /evidence="ECO:0007829|PDB:4O1N"
SQ   SEQUENCE   226 AA;  25647 MW;  729D9B2D02571A27 CRC64;
     MKFKAIAKAS LALGMLATGV ITSNVQSVQA KAEVKQQSES ELKHYYNKPI LERKNVTGFK
     YTDEGKHYLE VTVGQQHSRI TLLGSDKDKF KDGENSNIDV FILREGDSRQ ATNYSIGGVT
     KSNSVQYIDY INTPILEIKK DNEDVLKDFY YISKEDISLK ELDYRLRERA IKQHGLYSNG
     LKQGQITITM NDGTTHTIDL SQKLEKERMG ESIDGTKINK ILVEMK