SSL4_STAAE
ID SSL4_STAAE Reviewed; 308 AA.
AC A0A0H3K6A3;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 1.
DT 25-MAY-2022, entry version 28.
DE RecName: Full=Staphylococcal superantigen-like 4 {ECO:0000250|UniProtKB:Q2G1S8};
DE Flags: Precursor;
GN Name=ssl4 {ECO:0000250|UniProtKB:Q2G1S8}; OrderedLocusNames=NWMN_0391;
OS Staphylococcus aureus (strain Newman).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=426430;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Newman;
RX PubMed=17951380; DOI=10.1128/jb.01000-07;
RA Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT analysis of staphylococcal genomes: polymorphism and evolution of two major
RT pathogenicity islands.";
RL J. Bacteriol. 190:300-310(2008).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 109-308.
RX PubMed=22949551; DOI=10.1128/iai.00764-12;
RA Hermans S.J., Baker H.M., Sequeira R.P., Langley R.J., Baker E.N.,
RA Fraser J.D.;
RT "Structural and functional properties of staphylococcal superantigen-like
RT protein 4.";
RL Infect. Immun. 80:4004-4013(2012).
CC -!- FUNCTION: Secreted protein that plays a role in immune innate response
CC inhibition by interfering with host TLR2-mediated pathway.
CC {ECO:0000250|UniProtKB:Q2G1S8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2G1S8}.
CC -!- DOMAIN: The C-terminal domain contains a V-shape binding site for
CC sialyl Lewis X. {ECO:0000250|UniProtKB:Q2G0X7}.
CC -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC {ECO:0000305}.
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DR EMBL; AP009351; BAF66663.1; -; Genomic_DNA.
DR RefSeq; WP_000705644.1; NZ_CP023390.1.
DR PDB; 4DXF; X-ray; 1.70 A; A/B=109-308.
DR PDB; 4DXG; X-ray; 2.50 A; A=109-308.
DR PDBsum; 4DXF; -.
DR PDBsum; 4DXG; -.
DR AlphaFoldDB; A0A0H3K6A3; -.
DR SMR; A0A0H3K6A3; -.
DR EnsemblBacteria; BAF66663; BAF66663; NWMN_0391.
DR KEGG; sae:NWMN_0391; -.
DR HOGENOM; CLU_054950_1_0_9; -.
DR OMA; NAEQNRT; -.
DR Proteomes; UP000006386; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR008992; Enterotoxin.
DR InterPro; IPR015282; SSL_OB.
DR InterPro; IPR006126; Staph/Strept_toxin_CS.
DR InterPro; IPR008375; Staph_exotoxin.
DR InterPro; IPR016091; SuperAg_toxin_C.
DR InterPro; IPR013307; Superantigen_bac.
DR Pfam; PF09199; SSL_OB; 1.
DR PRINTS; PR01898; SAGSUPRFAMLY.
DR PRINTS; PR01800; STAPHEXOTOXN.
DR PRINTS; PR01501; TOXICSSTOXIN.
DR SUPFAM; SSF50203; SSF50203; 1.
DR SUPFAM; SSF54334; SSF54334; 1.
DR PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Secreted; Signal; Virulence.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..308
FT /note="Staphylococcal superantigen-like 4"
FT /evidence="ECO:0000255"
FT /id="PRO_5002613223"
FT REGION 28..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..278
FT /note="Sialyl Lewis X-binding"
FT /evidence="ECO:0000250|UniProtKB:Q2G0X7"
FT COMPBIAS 28..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 118..120
FT /evidence="ECO:0007829|PDB:4DXF"
FT HELIX 121..126
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 132..141
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 146..148
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 150..153
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 155..158
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 160..163
FT /evidence="ECO:0007829|PDB:4DXF"
FT HELIX 168..171
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 174..184
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 194..198
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 201..203
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 211..220
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 226..235
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 238..241
FT /evidence="ECO:0007829|PDB:4DXF"
FT HELIX 242..257
FT /evidence="ECO:0007829|PDB:4DXF"
FT TURN 260..262
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 265..272
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 277..281
FT /evidence="ECO:0007829|PDB:4DXF"
FT HELIX 288..291
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 294..296
FT /evidence="ECO:0007829|PDB:4DXF"
FT HELIX 297..299
FT /evidence="ECO:0007829|PDB:4DXF"
FT STRAND 300..308
FT /evidence="ECO:0007829|PDB:4DXF"
SQ SEQUENCE 308 AA; 34056 MW; 72A72A6CFC82FF2C CRC64;
MKITTIAKTS LALGLLTTGV ITTTTQAANA TTPSSTKVEA PQSTPPSTKI EAPQSKPNAT
TPPSTKVEAP QQTANATTPP STKVTTPPST NTPQPMQSTK SDTPQSPTTK QVPTEINPKF
KDLRAYYTKP SLEFKNEIGI ILKKWTTIRF MNVVPDYFIY KIALVGKDDK KYGEGVHRNV
DVFVVLEENN YNLEKYSVGG ITKSNSKKVD HKAGVRITKE DNKGTISHDV SEFKITKEQI
SLKELDFKLR KQLIEKNNLY GNVGSGKIVI KMKNGGKYTF ELHKKLQENR MADVIDGTNI
DNIEVNIK
