ID   SSL5_STAAE              Reviewed;         234 AA.
AC   A0A0H3K6Z6;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Staphylococcal superantigen-like 5 {ECO:0000250|UniProtKB:Q2G1S6};
DE   Flags: Precursor;
GN   Name=ssl5 {ECO:0000250|UniProtKB:Q2G1S6}; OrderedLocusNames=NWMN_0392;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   INDUCTION BY SAE.
RX   PubMed=20528938; DOI=10.1111/j.1574-6968.2010.02012.x;
RA   Pantrangi M., Singh V.K., Wolz C., Shukla S.K.;
RT   "Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively
RT   regulated by Sae and negatively by Agr in the Newman strain.";
RL   FEMS Microbiol. Lett. 308:175-184(2010).
CC   -!- FUNCTION: Secreted protein that plays a role in the inhibition of host
CC       innate immune system. Modulates the interaction between host SELPLG and
CC       P-selectin thereby preventing initial rolling of neutrophils toward the
CC       site of infection. Interferes with leukocyte trafficking by inhibiting
CC       host metalloproteinase-9/MMP9 activity. Associates also with two
CC       different platelet surface receptors GP1A and GP6 leading to platelet
CC       activation and aggregation. {ECO:0000250|UniProtKB:Q2G1S6}.
CC   -!- SUBUNIT: Interacts with host SELPLG; this interaction prevents SELPLG-
CC       mediated neutrophil rolling. Interacts with host MMP9 (via sialic acid-
CC       containing O-glycans); this interaction inhibits MMP9 activity.
CC       Interacts with host GP1BA and GP6; these interactions play an important
CC       role in platelet binding and activation.
CC       {ECO:0000250|UniProtKB:Q2G1S6}.
CC   -!- INDUCTION: Induced by Sae and repressed by Agr.
CC       {ECO:0000269|PubMed:20528938}.
CC   -!- SIMILARITY: Belongs to the staphylococcal/streptococcal toxin family.
CC       {ECO:0000305}.
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DR   EMBL; AP009351; BAF66664.1; -; Genomic_DNA.
DR   RefSeq; WP_000784244.1; NZ_CP023390.1.
DR   AlphaFoldDB; A0A0H3K6Z6; -.
DR   SMR; A0A0H3K6Z6; -.
DR   EnsemblBacteria; BAF66664; BAF66664; NWMN_0392.
DR   KEGG; sae:NWMN_0392; -.
DR   HOGENOM; CLU_054950_1_0_9; -.
DR   OMA; YIYKEEV; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   InterPro; IPR008992; Enterotoxin.
DR   InterPro; IPR015282; SSL_OB.
DR   InterPro; IPR006126; Staph/Strept_toxin_CS.
DR   InterPro; IPR008375; Staph_exotoxin.
DR   InterPro; IPR016091; SuperAg_toxin_C.
DR   InterPro; IPR013307; Superantigen_bac.
DR   Pfam; PF09199; SSL_OB; 1.
DR   PRINTS; PR01898; SAGSUPRFAMLY.
DR   PRINTS; PR01800; STAPHEXOTOXN.
DR   PRINTS; PR01501; TOXICSSTOXIN.
DR   SUPFAM; SSF50203; SSF50203; 1.
DR   SUPFAM; SSF54334; SSF54334; 1.
DR   PROSITE; PS00278; STAPH_STREP_TOXIN_2; 1.
PE   2: Evidence at transcript level;
KW   Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..234
FT                   /note="Staphylococcal superantigen-like 5"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5002613341"
SQ   SEQUENCE   234 AA;  27170 MW;  B8D2BA9C7FEC2CE9 CRC64;
     MKMTAIAKAS LALGILATGT ITSLHQTVNA SEHKAKYENV TKDIFDLRDY YSGASKELKN
     VTGYRYSKGG KHYLIFDKNR KFTRVQIFGK DIERFKARKN PGLDIFVVKE AENRNGTVFS
     YGGVTKKNQD AYYDYINAPR FQIKRDEGDG IATYGRVHYI YKEEISLKEL DFKLRQYLIQ
     NFDLYKKFPK DSKIKVIMKD GGYYTFELNK KLQTNRMSDV IDGRNIEKIE ANIR