ID   SSLA1_DICDI             Reviewed;         578 AA.
AC   P0DJ29; Q54PS2; Q54YC3; Q8MZN2;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Suppressor of smlA;
DE   AltName: Full=Protein secondary enhancer of smlA;
GN   Name=sslA1; ORFNames=DDB_G0284335;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND FUNCTION.
RX   PubMed=17660362; DOI=10.1128/ec.00169-07;
RA   Gao T., Roisin-Bouffay C., Hatton R.D., Tang L., Brock D.A., DeShazo T.,
RA   Olson L., Hong W.-P., Jang W., Canseco E., Bakthavatsalam D., Gomer R.H.;
RT   "A cell number-counting factor regulates levels of a novel protein, SslA,
RT   as part of a group size regulation mechanism in Dictyostelium.";
RL   Eukaryot. Cell 6:1538-1551(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in regulation of group size of aggregation streams.
CC       {ECO:0000269|PubMed:17660362}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P0DJ29-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P0DJ29-2; Sequence=VSP_032742;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM34288.2; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF508975; AAM34288.2; ALT_FRAME; mRNA.
DR   EMBL; AAFI02000064; EAL65215.2; -; Genomic_DNA.
DR   RefSeq; XP_638582.4; XM_633490.3.
DR   RefSeq; XP_642279.4; XM_637187.3.
DR   AlphaFoldDB; P0DJ29; -.
DR   STRING; 44689.DDB0191417; -.
DR   PaxDb; P0DJ29; -.
DR   GeneID; 8621486; -.
DR   GeneID; 8624555; -.
DR   KEGG; ddi:DDB_G0278309; -.
DR   KEGG; ddi:DDB_G0284335; -.
DR   dictyBase; DDB_G0284335; sslA1.
DR   HOGENOM; CLU_472093_0_0_1; -.
DR   InParanoid; P0DJ29; -.
DR   PRO; PR:P0DJ29; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0031982; C:vesicle; IDA:dictyBase.
DR   GO; GO:0031159; P:positive regulation of aggregate size involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0007165; P:signal transduction; IMP:dictyBase.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..578
FT                   /note="Suppressor of smlA"
FT                   /id="PRO_0000327960"
FT   VAR_SEQ         1..129
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17660362"
FT                   /id="VSP_032742"
SQ   SEQUENCE   578 AA;  67797 MW;  F8644298E196ACF9 CRC64;
     MRNEEAEKLF WIFNNKVRPI NYSEIVENTT PRKSSINREK IESENNGQVY NELFFFKLLL
     NEDLSKFLIS LINTNLRHER EKKLDKGKDI SRLNDLTDIT FWKFITDYLK NIYSNKNNDK
     IPPELINLKM MDHNRYSAVH NVLDMKSHRF EEYCEIFMNS ALKYINIGNV LNCDETIYAY
     YGKDAIKDHI LINNDSKPHS VGIEAYSLTT KLNISNCPYV ISYGPRTPEN CQSPFNSLKT
     LLDNLHSKYN WEDPRNNLIV CCDSAFALVN NKECLDELKC RILSSTRKSG VTVPQEIKIF
     VKPLLTIHKT FLFYDESTGL LYEYTKNTAG HINCIATNLY SRYSNPYVEI NNNLNIEQFA
     TIGNLFRFSK KELELIFVGE TLHGTTLEIL NGKYKTNFVK PPCGPFWNEQ MLKKLSAEHI
     AQIYNDKYKK ENNNLNKNDK IKKILEPLDS TQDGGIYDKN KNYSKKELQD LKIKVIGTHQ
     NRSQMIHDQY IFWYNLVDIT DKRYYATIRG SSSHSYTKLF ILGGLFDLIL NSYSLHREYH
     EMELECKNPE NQPPEIIQTI NKFVESLIFQ FHELKELQ