SSMM1_HUMAN
ID SSMM1_HUMAN Reviewed; 244 AA.
AC Q8WWF3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Serine-rich single-pass membrane protein 1;
GN Name=SSMEM1; Synonyms=C7orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8WWF3; Q92685: ALG3; NbExp=3; IntAct=EBI-17280858, EBI-2848814;
CC Q8WWF3; P02652: APOA2; NbExp=3; IntAct=EBI-17280858, EBI-1171525;
CC Q8WWF3; P29972: AQP1; NbExp=3; IntAct=EBI-17280858, EBI-745213;
CC Q8WWF3; Q96PS8: AQP10; NbExp=3; IntAct=EBI-17280858, EBI-12820279;
CC Q8WWF3; Q92482: AQP3; NbExp=3; IntAct=EBI-17280858, EBI-2808854;
CC Q8WWF3; P27449: ATP6V0C; NbExp=3; IntAct=EBI-17280858, EBI-721179;
CC Q8WWF3; O15155: BET1; NbExp=3; IntAct=EBI-17280858, EBI-749204;
CC Q8WWF3; P62952: BLCAP; NbExp=3; IntAct=EBI-17280858, EBI-3895726;
CC Q8WWF3; Q96F05: C11orf24; NbExp=3; IntAct=EBI-17280858, EBI-2836238;
CC Q8WWF3; Q86Z23: C1QL4; NbExp=3; IntAct=EBI-17280858, EBI-12062109;
CC Q8WWF3; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-17280858, EBI-12003442;
CC Q8WWF3; P01031: C5; NbExp=3; IntAct=EBI-17280858, EBI-8558308;
CC Q8WWF3; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-17280858, EBI-10271156;
CC Q8WWF3; O95674: CDS2; NbExp=3; IntAct=EBI-17280858, EBI-3913685;
CC Q8WWF3; A0PK11: CLRN2; NbExp=3; IntAct=EBI-17280858, EBI-12813623;
CC Q8WWF3; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-17280858, EBI-2807956;
CC Q8WWF3; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-17280858, EBI-10267100;
CC Q8WWF3; Q07325: CXCL9; NbExp=3; IntAct=EBI-17280858, EBI-3911467;
CC Q8WWF3; P49447: CYB561; NbExp=3; IntAct=EBI-17280858, EBI-8646596;
CC Q8WWF3; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-17280858, EBI-2680384;
CC Q8WWF3; P81534: DEFB103B; NbExp=3; IntAct=EBI-17280858, EBI-12074168;
CC Q8WWF3; Q5J5C9: DEFB121; NbExp=3; IntAct=EBI-17280858, EBI-10244198;
CC Q8WWF3; P52803: EFNA5; NbExp=3; IntAct=EBI-17280858, EBI-1753674;
CC Q8WWF3; Q08426: EHHADH; NbExp=3; IntAct=EBI-17280858, EBI-2339219;
CC Q8WWF3; P50402: EMD; NbExp=3; IntAct=EBI-17280858, EBI-489887;
CC Q8WWF3; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-17280858, EBI-711490;
CC Q8WWF3; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-17280858, EBI-10976398;
CC Q8WWF3; Q92520: FAM3C; NbExp=3; IntAct=EBI-17280858, EBI-2876774;
CC Q8WWF3; Q969F0: FATE1; NbExp=3; IntAct=EBI-17280858, EBI-743099;
CC Q8WWF3; P14324: FDPS; NbExp=3; IntAct=EBI-17280858, EBI-948245;
CC Q8WWF3; P25090: FPR2; NbExp=3; IntAct=EBI-17280858, EBI-17291771;
CC Q8WWF3; O43681: GET3; NbExp=3; IntAct=EBI-17280858, EBI-2515857;
CC Q8WWF3; P29033: GJB2; NbExp=3; IntAct=EBI-17280858, EBI-3905204;
CC Q8WWF3; Q86YW7: GPHB5; NbExp=3; IntAct=EBI-17280858, EBI-11659720;
CC Q8WWF3; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-17280858, EBI-11955647;
CC Q8WWF3; P30519: HMOX2; NbExp=3; IntAct=EBI-17280858, EBI-712096;
CC Q8WWF3; O43561-2: LAT; NbExp=3; IntAct=EBI-17280858, EBI-8070286;
CC Q8WWF3; O95214: LEPROTL1; NbExp=3; IntAct=EBI-17280858, EBI-750776;
CC Q8WWF3; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-17280858, EBI-12133176;
CC Q8WWF3; Q9P0N8: MARCHF2; NbExp=3; IntAct=EBI-17280858, EBI-10317612;
CC Q8WWF3; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-17280858, EBI-348259;
CC Q8WWF3; Q6NUT3-2: MFSD12; NbExp=3; IntAct=EBI-17280858, EBI-17295698;
CC Q8WWF3; Q6N075: MFSD5; NbExp=3; IntAct=EBI-17280858, EBI-3920969;
CC Q8WWF3; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-17280858, EBI-2858252;
CC Q8WWF3; P30301: MIP; NbExp=3; IntAct=EBI-17280858, EBI-8449636;
CC Q8WWF3; Q8IY49-2: MMD2; NbExp=3; IntAct=EBI-17280858, EBI-13349813;
CC Q8WWF3; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-17280858, EBI-12070086;
CC Q8WWF3; Q0D2K0: NIPAL4; NbExp=3; IntAct=EBI-17280858, EBI-9550165;
CC Q8WWF3; Q8IXM6: NRM; NbExp=3; IntAct=EBI-17280858, EBI-10262547;
CC Q8WWF3; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-17280858, EBI-12092917;
CC Q8WWF3; O14494: PLPP1; NbExp=3; IntAct=EBI-17280858, EBI-2865290;
CC Q8WWF3; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-17280858, EBI-10485931;
CC Q8WWF3; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-17280858, EBI-11721828;
CC Q8WWF3; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-17280858, EBI-12955265;
CC Q8WWF3; Q59EV6: PPGB; NbExp=3; IntAct=EBI-17280858, EBI-14210385;
CC Q8WWF3; Q02161-2: RHD; NbExp=3; IntAct=EBI-17280858, EBI-17249212;
CC Q8WWF3; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-17280858, EBI-10244780;
CC Q8WWF3; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-17280858, EBI-8636004;
CC Q8WWF3; Q9H228: S1PR5; NbExp=3; IntAct=EBI-17280858, EBI-2564169;
CC Q8WWF3; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-17280858, EBI-10329948;
CC Q8WWF3; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-17280858, EBI-8644112;
CC Q8WWF3; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-17280858, EBI-10262251;
CC Q8WWF3; P78382: SLC35A1; NbExp=3; IntAct=EBI-17280858, EBI-12870360;
CC Q8WWF3; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-17280858, EBI-12363689;
CC Q8WWF3; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-17280858, EBI-17295964;
CC Q8WWF3; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-17280858, EBI-13389236;
CC Q8WWF3; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-17280858, EBI-9978441;
CC Q8WWF3; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-17280858, EBI-10314552;
CC Q8WWF3; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-17280858, EBI-12898013;
CC Q8WWF3; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-17280858, EBI-2823239;
CC Q8WWF3; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-17280858, EBI-12266234;
CC Q8WWF3; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-17280858, EBI-10290130;
CC Q8WWF3; Q9UNK0: STX8; NbExp=3; IntAct=EBI-17280858, EBI-727240;
CC Q8WWF3; Q03518: TAP1; NbExp=3; IntAct=EBI-17280858, EBI-747259;
CC Q8WWF3; Q9NYW0: TAS2R10; NbExp=3; IntAct=EBI-17280858, EBI-12963900;
CC Q8WWF3; Q96CP7: TLCD1; NbExp=3; IntAct=EBI-17280858, EBI-11337932;
CC Q8WWF3; Q9BZW4: TM6SF2; NbExp=3; IntAct=EBI-17280858, EBI-13082040;
CC Q8WWF3; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-17280858, EBI-10694905;
CC Q8WWF3; Q7Z5S9: TMEM144; NbExp=3; IntAct=EBI-17280858, EBI-12876358;
CC Q8WWF3; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-17280858, EBI-2800360;
CC Q8WWF3; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-17280858, EBI-2339195;
CC Q8WWF3; Q969S6: TMEM203; NbExp=3; IntAct=EBI-17280858, EBI-12274070;
CC Q8WWF3; A2RU14: TMEM218; NbExp=3; IntAct=EBI-17280858, EBI-10173151;
CC Q8WWF3; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-17280858, EBI-347385;
CC Q8WWF3; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-17280858, EBI-11528917;
CC Q8WWF3; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-17280858, EBI-12887458;
CC Q8WWF3; Q9NWC5: TMEM45A; NbExp=3; IntAct=EBI-17280858, EBI-10823938;
CC Q8WWF3; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-17280858, EBI-2852148;
CC Q8WWF3; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-17280858, EBI-12015604;
CC Q8WWF3; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-17280858, EBI-2548832;
CC Q8WWF3; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-17280858, EBI-12111910;
CC Q8WWF3; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-17280858, EBI-11724433;
CC Q8WWF3; P01375: TNF; NbExp=3; IntAct=EBI-17280858, EBI-359977;
CC Q8WWF3; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-17280858, EBI-11988865;
CC Q8WWF3; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-17280858, EBI-4401271;
CC Q8WWF3; O75841: UPK1B; NbExp=3; IntAct=EBI-17280858, EBI-12237619;
CC Q8WWF3; O75379: VAMP4; NbExp=3; IntAct=EBI-17280858, EBI-744953;
CC Q8WWF3; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-17280858, EBI-751210;
CC Q8WWF3; O95159: ZFPL1; NbExp=3; IntAct=EBI-17280858, EBI-718439;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK097635; BAC05126.1; -; mRNA.
DR EMBL; BC017587; AAH17587.1; -; mRNA.
DR CCDS; CCDS5816.1; -.
DR RefSeq; NP_660311.1; NM_145268.3.
DR AlphaFoldDB; Q8WWF3; -.
DR BioGRID; 126451; 115.
DR IntAct; Q8WWF3; 110.
DR STRING; 9606.ENSP00000297819; -.
DR iPTMnet; Q8WWF3; -.
DR PhosphoSitePlus; Q8WWF3; -.
DR BioMuta; SSMEM1; -.
DR DMDM; 74730975; -.
DR MassIVE; Q8WWF3; -.
DR PaxDb; Q8WWF3; -.
DR PeptideAtlas; Q8WWF3; -.
DR PRIDE; Q8WWF3; -.
DR ProteomicsDB; 74880; -.
DR Antibodypedia; 17943; 61 antibodies from 10 providers.
DR DNASU; 136263; -.
DR Ensembl; ENST00000297819.4; ENSP00000297819.3; ENSG00000165120.5.
DR GeneID; 136263; -.
DR KEGG; hsa:136263; -.
DR MANE-Select; ENST00000297819.4; ENSP00000297819.3; NM_145268.4; NP_660311.1.
DR UCSC; uc003vpp.4; human.
DR CTD; 136263; -.
DR GeneCards; SSMEM1; -.
DR HGNC; HGNC:29580; SSMEM1.
DR HPA; ENSG00000165120; Tissue enriched (testis).
DR neXtProt; NX_Q8WWF3; -.
DR OpenTargets; ENSG00000165120; -.
DR PharmGKB; PA162380490; -.
DR VEuPathDB; HostDB:ENSG00000165120; -.
DR eggNOG; ENOG502S512; Eukaryota.
DR GeneTree; ENSGT00390000015907; -.
DR HOGENOM; CLU_099475_0_0_1; -.
DR InParanoid; Q8WWF3; -.
DR OMA; ECQKDDS; -.
DR OrthoDB; 1140894at2759; -.
DR PhylomeDB; Q8WWF3; -.
DR TreeFam; TF337221; -.
DR PathwayCommons; Q8WWF3; -.
DR SignaLink; Q8WWF3; -.
DR BioGRID-ORCS; 136263; 14 hits in 1068 CRISPR screens.
DR GenomeRNAi; 136263; -.
DR Pharos; Q8WWF3; Tdark.
DR PRO; PR:Q8WWF3; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8WWF3; protein.
DR Bgee; ENSG00000165120; Expressed in buccal mucosa cell and 39 other tissues.
DR ExpressionAtlas; Q8WWF3; baseline and differential.
DR Genevisible; Q8WWF3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR027955; DUF4636.
DR PANTHER; PTHR31822; PTHR31822; 1.
DR Pfam; PF15468; DUF4636; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..244
FT /note="Serine-rich single-pass membrane protein 1"
FT /id="PRO_0000271354"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 65..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 88
FT /note="R -> W (in dbSNP:rs4728190)"
FT /id="VAR_029873"
SQ SEQUENCE 244 AA; 28167 MW; 14EB74E45FE0303D CRC64;
MGDLFSLFWE VDPPPIPVNC AIPNQDYECW KDDSCGTIGS FLLWYFVIVF VLMFFSRASV
WMSEDKKDEG SGTSTSVRKA SKETSCKRQS KDSAWDPSQT MKKPKQNQLT PVTNSEVALV
NAYPEQRRAR RQSQFNEVNQ NQHDSDTTEY GSEESNSEAS SWKESESEHH PSPDSIKRRK
MAQRQRNLGS YQMSERHCLH CKALRTNEWL AHHSRQKPSV TPPMKRDSQE ESSISDINKK
FSKF
