SSN2_ASHGO
ID SSN2_ASHGO Reviewed; 1357 AA.
AC Q756F6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13;
DE AltName: Full=Mediator complex subunit 13;
GN Name=SSN2; Synonyms=MED13; OrderedLocusNames=AER323W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000305}.
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DR EMBL; AE016818; AAS53003.1; -; Genomic_DNA.
DR RefSeq; NP_985179.1; NM_210533.1.
DR AlphaFoldDB; Q756F6; -.
DR SMR; Q756F6; -.
DR STRING; 33169.AAS53003; -.
DR PRIDE; Q756F6; -.
DR EnsemblFungi; AAS53003; AAS53003; AGOS_AER323W.
DR GeneID; 4621392; -.
DR KEGG; ago:AGOS_AER323W; -.
DR eggNOG; KOG3600; Eukaryota.
DR HOGENOM; CLU_242296_0_0_1; -.
DR InParanoid; Q756F6; -.
DR OMA; FSRELWC; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:1990508; C:CKM complex; IEA:EnsemblFungi.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0000435; P:positive regulation of transcription from RNA polymerase II promoter by galactose; IEA:EnsemblFungi.
DR GO; GO:0006468; P:protein phosphorylation; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR Pfam; PF06333; Med13_C; 2.
DR Pfam; PF11597; Med13_N; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1357
FT /note="Mediator of RNA polymerase II transcription subunit
FT 13"
FT /id="PRO_0000314245"
FT REGION 356..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1357 AA; 153091 MW; 883206E7DBB8F26E CRC64;
MDILETSFRL EDVLSSYYRV EKVVRVNYQQ FVPRTPDDQW CIQSELLIRK KDPKALVALF
SRELWCFSIN DQDLPMPGLE GIGEPPNSEK KGHFTPGFSK PNLPTPYAIF LKALRRMIHI
NMCLRSQNRL VPFGNTCIFQ RDEKASSVIH FDSHLFENGD LTVSLCTKDM GFERLLSGAF
TGRQVKRALY LAPSGIRAYL PFPDISKCLV APPKNAHLLL VTLLVSHGID LTQAKDLKWI
KLVPNINHLN GYTPTISRYA EESQTSKSVI WPMDLCFQQT PADACVNTTR ATPLDIGLQD
SFDLIEDFIQ LKLTSAYRIP GTSVNANTAT GNNPLSTGGG FTDQFQPFVK HTNSSSCNYG
PASRTKLTPS KAQDLRRSAA PLSADSFGNG FMTTPNVNEN MGSVIDDMVI CPSSVKSQND
LWNDRKSSND DIDSINPTSQ QGDSARITSG SEEQDVEVTF DKDLFGDEDD ESDLFGDSSN
KSTHRKEVRE ITDEMFDSAE IESDPEGKIT PTGTSINYST QQQTPLKRKY LDIPLDEITL
PAAPLYTDPG APLPVETPRD RRKSVFAPLN FNPMIESNVD NKYKNGGKFS FDPNEIDEPL
KFEVSTTNIS SSEEDDSEFS GDDFDELQQN NLQDIRAMEV GSSLQQYDMG RPINEFLNQS
DSAKEDYLLP AYQSGDVIDV DKFPSRESHL DQIWKSPEIN REDTPHRIGL PIIKPQLDGS
GNLDIDNQIT DNCSSNYYEP TPVVGADEKI QERTLHKDKK LDQQGDSAMA SVVGDYSLAI
KETRESSNGL PFLLRHMPLF SIPDVFLSKN PIVKVDSKLE DFLEILCEQL VFDQGFLGNF
DVDPPTYKDV KLNEKGVIRE TLNSVFSEFE RLRGNEIISD MFYIKQPSVC VKKHGNLIKL
KSDAESFAPL LHLKPSRGMK SFRGLFLTTI LTQTCVSFIT ELAHIYSAQE LGFCELVKLT
NDEHNGLIVL NNFNTDTLLL LSAQIVSYCS TNMNNVKNIP LMIFLPVAPS SLEATITMTS
KFQLIKNEVK SRLPDVELLL KLIPFDLTKD PVIMIDRYYE LCRGIYNLLP PRTVKFASIA
DNLPEQVEFR TSAGNQNQLS HYDSYIHLAY TRSIDREWLA AAWSDSKGTE NMVKAWYLGN
SKARFETACN ELWKLTVELA SRKYGRICLI LTRMDSVLPD DELMHWRRLS VTTRNLHLAV
VCVGASTKVS LYDEDQFYPS FKPLFKDKRY ANKIQANQLD DYEVVNIDEE LHGVVFSSPL
QLANSQHRCA IKSGALVRFK RCAGGDTLDK FEVNLLNCPH SDSTKLLKTI LHQFRDIASL
NTWFCISRGK DNYIPWHVVA VKKIMRFIIH VNGIEEK
