ID   SSN2_CANAL              Reviewed;        1665 AA.
AC   Q5ALX5; A0A1D8PGD4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 13;
DE   AltName: Full=Mediator complex subunit 13;
GN   Name=SSN2; Synonyms=MED13, SRB9; OrderedLocusNames=CAALFM_C201470WA;
GN   ORFNames=CaO19.1451, CaO19.9026;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC       the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC       {ECO:0000305}.
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DR   EMBL; CP017624; AOW27193.1; -; Genomic_DNA.
DR   RefSeq; XP_722501.1; XM_717408.2.
DR   AlphaFoldDB; Q5ALX5; -.
DR   BioGRID; 1218939; 2.
DR   STRING; 237561.Q5ALX5; -.
DR   PRIDE; Q5ALX5; -.
DR   GeneID; 3635845; -.
DR   KEGG; cal:CAALFM_C201470WA; -.
DR   CGD; CAL0000184111; SRB9.
DR   VEuPathDB; FungiDB:C2_01470W_A; -.
DR   eggNOG; KOG3600; Eukaryota.
DR   HOGENOM; CLU_242296_0_0_1; -.
DR   InParanoid; Q5ALX5; -.
DR   OMA; FSRELWC; -.
DR   OrthoDB; 120348at2759; -.
DR   PRO; PR:Q5ALX5; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR   GO; GO:0030448; P:hyphal growth; IMP:CGD.
DR   GO; GO:1900233; P:positive regulation of single-species biofilm formation on inanimate substrate; IMP:CGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR   InterPro; IPR009401; Med13_C.
DR   InterPro; IPR021643; Mediator_Med13_N.
DR   Pfam; PF06333; Med13_C; 1.
DR   Pfam; PF11597; Med13_N; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1665
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   13"
FT                   /id="PRO_0000314246"
FT   REGION          411..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..445
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..512
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..719
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..781
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1665 AA;  186571 MW;  D998433D56A533EF CRC64;
     MVGANASSIS TQYYKLAHLG SISYTIYTSS DNNDQALLEL ELTIRHKWPQ ILVTYYNKSL
     YYFVFGHNKV DSETIDLTKE FPQLSTKYTD TVNVDQFPNP HKSTKNDDNL AWASLSFLKA
     TKKMILYNLS LSGAIKLFGN YCVAPTGDSV YSILCIDPIL FQNGDLVVSC VEKPFTQLFS
     SSVAYPRNLA IDTNFVIYLI PSGIRCHLFD PTSLRNNLIE KPQIENGKLL ELLKITTGVQ
     CDESTLWVKL IPNLKHLNNQ TSAIGKFIHS VENKKFILWP WDLCLLQFGK FEPAIEEEGL
     LESSELNNPL HLISDFLDFR IAHNTQLQQQ RDSLSDQQQG ETVNVPLSAG SVHATGANSF
     GNVPDISKDV DTVGLSTTTP IETDLFNLQN TEEFFKNDSI HMNLEDQIHK KETEPENESE
     NDMEIDDLFG GDESDDNDDL EEAGNEEEKP TPSNNTIDKN GVIGNALEEA FIADATPSKE
     NINLDSKIMP PDSTSEEAVP DKENFKPKET KPSYIDILKD KMTIEKIVNS PDYKDPGAPL
     PVVPTPLVSS TVSQSAVTTN PPSVGSAPGP APGPAPGTET LYEANNAYAQ SSQISQLPQQ
     KSAFSPILFN PIIKSDIDTK YGKGGKFYVA KDSSTNGNLD MKNRSLRATS VSGMEIPFSS
     EDKKRLQQNL EVLDSSTTSD NEGGEDIEDD DNDYEDEGDD DEEEEGEEEE EEESDEDEIS
     DIGKSTPLKL NTQNESVPPQ QSNYNPVNIT DSGSNTTNNI TDKQGYENTE GFGTPFPNQI
     SKYSIKPESP FASNELQSSV SPMYFDTSQS HQSPQLQPST GTLEVLKASS LESPSKISES
     SNYLPLILRS INVSTIPSSY LMNNLISSKL LPSFTISDDD LENDLDITKS NEMIVKLGFL
     KEFLDFMSPN IIFDLGLMKN DESDYYINGV NDLLLNSDPG ISSDWILNSL SKVFPCTYPM
     KLIELLYDFK SLELEDQLDS QLNFLNEIAD EEDFVGPKAL YRKLKALEWD SFSLNESNKT
     SFEKYKNVME KLSAENTVSD DDYFKLPMVK TRILKNGNIV NLNNIGLKFW KYLNFSPVKK
     QKDFQILLIA ETHRNTASYA TEFLDQIIQN YKECNFGTIS KVNLSTVETR SDLEPISDGL
     VLVHKEHDQS YNDFYIQTNK KLISLVELIK LDLINKTNNF EFGKPLLLFF IDFNDSSNSN
     VQVCKIFRNF KVALTTHQLP LVDIFTKIVP SSLLVKKVHH ETALKVFSNY KLTKISMNLY
     NECPNDLANK SIVKNLFTTI VKDPPSKIQF KFMNSSYRDN SSNDDIFLHL AYERSIDNSW
     FVASWSDPLG RVVHVKSWYC SDSVSKSEKS TYRGDIMDIM SITDDIWSIS TDLFKVLNDE
     LGSFGGKKFL VLTRINSIIP DVELVHWKRL SSKHKEISLI VVSVRQTPRI VGSNESEDLG
     PKSNDYAPTP MIQDKDIFFG FKQTFSTSNT SSPSASGGAL VTSPNSLSLH SPQQFLNAPA
     NFLSPQDLIA PTSSGISGAK PGSSGIDPEV VLENQDNEVY GVIPKVPLPS FNSPTRFCMK
     TGYLMMQVNQ PSEEEYKDDI KKTYLVYEIN LLSCSNYWNL DVLMKLIMSQ YKQMIALNDI
     LCMNPIVGES DILGTHSRNN AIVPWHINAV GKLLDYLVHI YVDKD