SSN2_DEBHA
ID SSN2_DEBHA Reviewed; 1774 AA.
AC Q6BZF6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13;
DE AltName: Full=Mediator complex subunit 13;
GN Name=SSN2; Synonyms=MED13; OrderedLocusNames=DEHA2A01716g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000305}.
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DR EMBL; CR382133; CAG84365.2; -; Genomic_DNA.
DR RefSeq; XP_456413.2; XM_456413.1.
DR AlphaFoldDB; Q6BZF6; -.
DR STRING; 4959.XP_456413.2; -.
DR PRIDE; Q6BZF6; -.
DR EnsemblFungi; CAG84365; CAG84365; DEHA2A01716g.
DR GeneID; 2899630; -.
DR KEGG; dha:DEHA2A01716g; -.
DR VEuPathDB; FungiDB:DEHA2A01716g; -.
DR eggNOG; KOG3600; Eukaryota.
DR HOGENOM; CLU_242296_0_0_1; -.
DR InParanoid; Q6BZF6; -.
DR OMA; FSRELWC; -.
DR OrthoDB; 120348at2759; -.
DR Proteomes; UP000000599; Chromosome A.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..1774
FT /note="Mediator of RNA polymerase II transcription subunit
FT 13"
FT /id="PRO_0000314248"
FT REGION 394..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 437..506
FT /evidence="ECO:0000255"
FT COMPBIAS 394..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..734
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1774 AA; 199037 MW; 927896D092329DCA CRC64;
MPEAIDASSI ATNYYKLAHL CSVTYLIYTT NGATNDSTLL ELELLIRHSH PKCLVTYYNK
YLYYFQFNHV DEHVDLTKEY PQLQLKYSNQ VSADLLANPP KVASDKDNHS TGNEYLAYAC
LSFLKAVKKL VLFNLSRNEA VQLFGNYAVV KEQGLSNFIL HIDPILLPNG DLLISISEKC
HLQLFDSSIV DISEIEAVDL NFVLYIIPSG IRCHLYDNVN VASNFTTDPP KNSEVLMQLI
KYSTGFDLNQ LNSLVWVKLV PNLQHLNNQT SKISKFIHPV DNKKFILWPW RLCLLQFGLS
EKDTATSPHV LTCDPISLIS DFIDFNISHH QQANITGQLN PNHQHNQSFN YSIPSALSTG
MSSTGANENK GDLNMVGDIP GSVSDIFGIQ SSDTNDFFNG PNFQPAQNPS DVKLDSQEPV
KKNSDDEDVE MDDLFGDASE DEKAKTEVST NELNEEKNFE DLFNDGLNQE NQVDESDKVA
KSIDEEVLKE ESVKSEDLKE DKDLKMQPSS GTIPNTFIDI PKDQMTIPSL KNLKQTPQIY
NDPGAPMPVI PTPIFPQFGI NSTLPGSAQS VNPPTSAAAT DNEANEGARS IFSPILFNPI
IKSNIDTKYG KGGKFYVDKE VSAGPDIDSK RKTLRATSVS GFELPSRRED SIGIESITDD
NDRRQVFEFP EEQGNERMKD EGHENHAAEN DNIIKKMEEL EEEDDNDDDD DDDDDDDENE
DEDEESDEDD DLNLENNDMN MKRSPPLKLN TLNDPYVAQS NQAVVNFNDS NYNAKQILPN
SYNASSMNTG GFSSPASLGF SSSRTNVPPK NDSPFGLNNL AREDRNGTTS PTGDNSDQPT
KRQEQSDSPM VVDMEVEKKS TSKEAENTPS GMTTPNSRGS ISESSNCLPL ILRGVNVASI
PTSFILNNVI VSNKISTIST NFDMDVDDET EWSDYELCKN NEMTVKLNNL DEFLKCLGPN
LIFDMGLNKL QNSLEMKLSN NERDDEEYDN IEGKAPSRQF ENKLCDIFPF CYKVNLNEFT
TEAYVNELKG ETTTIQDELD NQLSFLDDIT NEDILNPKTQ LKKLNSIEWD AIYSDSSSNE
DNSKKYQGMV HNVGQSSLVN TLEDGTIFPL ANDKARVLKH NDTIINLNSI GIKFWKYLNF
SPLNGPKNFQ LLLISEHDHN MLHHNYNIEF LNSLVYNYKE CCFGNISKIN LQSSDSRPDM
EGIDNGLLMV HKKDEDQVYG NMYKQVNRKL NALVEMIKSD LINKTNKFEF DRPLLLLFIN
FDKSVNSLLQ ISKLIRNFKL FLSHHQLPLV EVFAHIIPWS LIIKQSGSQR RLKYLSNFRL
SKLSMNLYNQ CPNERTIGKP VKDPTKHLFT QLVKEPPSNL NFKFMNNGSN GNGKTTFNDD
IFLHLAYERS IDKNWFSAAW SDPLGVVVST KSWNCSPNLQ KTNNKNVHSL ESISDEIWTI
STALFKKLND EIIKRTSGLG GKKFLVLTRI NSIIPDDELI HWKRLSMKHK DVSLIVLSVN
KSPKLLFSGP IGPSQQEDKS NYDPNTNRTS TNMDNSSSTN AANPTCGVGA TSNAPDFFKT
FGSNNPSPNN NAGSMSISPS NNVGINFHSP QQFLNAPGNF LLPQDFVSST GGSTNINANP
HSNASQYNPD EIIHDPTEEL TAVIPKAPLP SFNSPTRLGM KIGYLIKETG VSTHEDTKQY
LVYEINLLSC SNYWNLNAIM KILLNQYKKL ITLNDILCVG EIDGSITDDR AEKDSNIIPE
MTPPLNYTAS GLIPWHIAAV TKSLDYLIHI DVEE
