SSN2_PICST
ID SSN2_PICST Reviewed; 1660 AA.
AC A3LN53;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13;
DE AltName: Full=Mediator complex subunit 13;
GN Name=SSN2; Synonyms=MED13; ORFNames=PICST_66803;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000305}.
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DR EMBL; CP000496; ABN64267.2; -; Genomic_DNA.
DR RefSeq; XP_001382296.2; XM_001382259.1.
DR AlphaFoldDB; A3LN53; -.
DR STRING; 4924.XP_001382296.2; -.
DR PRIDE; A3LN53; -.
DR EnsemblFungi; ABN64267; ABN64267; PICST_66803.
DR GeneID; 4836799; -.
DR KEGG; pic:PICST_66803; -.
DR eggNOG; KOG3600; Eukaryota.
DR HOGENOM; CLU_242296_0_0_1; -.
DR InParanoid; A3LN53; -.
DR OMA; FSRELWC; -.
DR OrthoDB; 120348at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1660
FT /note="Mediator of RNA polymerase II transcription subunit
FT 13"
FT /id="PRO_0000314251"
FT REGION 94..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..461
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1660 AA; 185501 MW; FE191B32DA2F5AFD CRC64;
MSEATASNIS THYYKLGHLG TVSFYNYVSF TDNDQSLLEL ELSIRYAHPN ILVTYYNKSL
YYFTFGHNNV PLETVSRDIE LPDLAKDINT DVDLSKDVTG PNPGANNSPS LLANPPKSAS
SGSTLGAAVD EYLPFASLSL LKSIKKMILF NLSKNGAIKL FGNYCVVARD TINRSILYLD
PILFPNGDLL LSMVVKERIN LLDSSIIDLK YPSQDAPDIN FVIYLIPSGI RCHLFDPTNL
VRNFVRKKSA ESENLIDLIK LSTGVEYSFN SEEENVWIKL IPNLKHLNNQ TSTIAKFIHS
VDNKKFILWP WKLCLLQFGK FEEVDEITSP DVTSSQVHPT SNPLDLIGDL IDFNISSNQH
HNFAQPSQTL PFSISSVAST GGDAGIGSVD PHTTMEQQPH TLDLNDITTH MVPDLFDLQN
PVPSEFFTKE VQDMPPVDGT EVKEDTNQDD VEMDDLFGGS DDEGDDSRNG QNSSKEDLFS
DAIKEEPKDA LAAGTPAELE KNQLNDLFDI SDKEAAPDSG KYSTPAKEPK FKYLDIPKDQ
MTIKKSSSPD YNDPGAPLPI MPTPIIPVAN SVYSTNPPTA AAIGTEGVGL SDDQSSGPYN
QPQPKQEIFN SGSSASQIQQ KSIFSPILFN PIIKSNIDTK YGKGGKFYVD KEASIGPEEK
KKKTFRETSV SGYELPLTKE EDKLPITAQA VGLRKMNNSS LSLAESSMSA SSEESDEDEE
MPDVISNSPP LRLNTFNDSF GGVPMGNSGG ITLNNNPINL SNYNTGGFGS PNSSVIGRFP
NIKGESPFST ADLQQTVSPI DYEQSNNQHT PSFPTSQGLQ ITQSVNNGSG RTSSSDESPV
KGISESSNYL PLILRSINVS TIPDIYLLNN LISDQLLPSF TINDDDNDND LEVMRNNEMF
IKAKHLDEFL ELIGPNLVFD LGFNQGRSKL SYYMDELVKS KLEENKVFPN SYKVNLIEFL
NDQKDYESKD ELEDQLDFLD DIANDDDNIL NPKSQYKKLK SIEWDALTEN TKNKENFEKY
KLIVNKLNSS VSTKDEVYFK LPIIKARVLK HNNILNLNNL AINFWKYMNF SPIKSTKHFQ
VLLISENNGN GTSFLREFLD LLIYNYKECN LGHISKVNLS TVETRPDLEN INDGILLVNK
DNDQTYNDTY SQINKKLNSL VELIKLDLIN KTNNFEFDRP LLLLFVNYND NLNSTLQISK
VFRNLKVSLT NHQLPLVSIF TKIIPGSLIV KQDPFQNWLK VLSNFKLSKL SMNLYNQCPN
GSTNKDIVKN TFTQLVKEPP SRIQFKFMSN NFKHSNFNDD IFLHLAYERS IDRNWFSAAW
SDPLGVVTFT KSWYCSNKAT RNGSGGYGRD THDVATVCEE IWNKSNELFK KLNDEMNNES
STMGGKKFLV LTRINSIIPD DELIHWKRLS VKHKDISLIV LSVSHSPKLI FQDNRPRFED
TENCGQLDNF FKVFSGSNNS SPTTGGALVT SPNVLSFHSP QQFLNAPGNF LSPQDFVSTA
GGAGAGATSA PHGGSNNPDL ILHDFGTDVI GIIPKVPLPS FNSPTRLGMK IGYLLKEWMN
GSRSTSRPRR SYLVYEVSLL SCSNYWDLDV LMKLILNHYK NLIVLNDILG LRKIDGNISK
NESEDDFEQS LEFEASGIVP WHISAVGKSL VYLSHIYVDE
