ID   SSN8_ASHGO              Reviewed;         332 AA.
AC   Q75AX7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN   Name=SSN8; OrderedLocusNames=ADL207W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS51713.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016817; AAS51713.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_983889.1; NM_209242.1.
DR   AlphaFoldDB; Q75AX7; -.
DR   SMR; Q75AX7; -.
DR   STRING; 33169.AAS51713; -.
DR   GeneID; 4620031; -.
DR   KEGG; ago:AGOS_ADL207W; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   InParanoid; Q75AX7; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..332
FT                   /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT                   /id="PRO_0000314265"
FT   DOMAIN          74..175
FT                   /note="Cyclin N-terminal"
SQ   SEQUENCE   332 AA;  38204 MW;  7BFA29CD627CCC7B CRC64;
     MSASYWDSSQ RNKWQYSRES LARTRQKLWM LECQLYPQGT NILMEGGGKD AQPVTKNIPI
     THRDLHYDRD YNLRIYCYFL IMKLGRRLNV RQYALATAHV YLARFCLKAS IREVNLYLLV
     TTCIYLACKV EECPQHIRTL VNEARSLWPE FVPPDPTKVT EFEFYLIEEL QSYMIVHYPY
     RAMEQIAAAL RRPPYNLVLS PDDLQNSWSL INDSYITDVH LLYPPHVIAM ACLFITVCLR
     SAAGARDLQE TFNRFMADSQ VDLHEVMDTI QDFITLYDHW DKYNEPWIKF LLHNLYLRPH
     AGGTTVSGAA AGSAGPAGSV LTPNGTITGS TS