ID   SSN8_ASPOR              Reviewed;         301 AA.
AC   Q2UDB2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN   Name=ssn8; ORFNames=AO090012000244;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Component of the srb8-11 complex. The srb8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The srb8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The srb8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the srb8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE60453.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP007161; BAE60453.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001727292.2; XM_001727240.2.
DR   AlphaFoldDB; Q2UDB2; -.
DR   SMR; Q2UDB2; -.
DR   STRING; 510516.Q2UDB2; -.
DR   EnsemblFungi; BAE60453; BAE60453; AO090012000244.
DR   VEuPathDB; FungiDB:AO090012000244; -.
DR   OMA; SHHQQWL; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..301
FT                   /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT                   /id="PRO_0000314268"
FT   DOMAIN          53..142
FT                   /note="Cyclin N-terminal"
SQ   SEQUENCE   301 AA;  34418 MW;  5FC0BDD9FB106BF1 CRC64;
     MAANYWASTQ RRHWLFTKER LADIRESFRE RDKAAHSQFP LPDQRLLNIY FSQQLIKLGK
     RMSTRQQALA TAQVYIKRFY TKNEIRHTNP YLVVTTAFYL ACKMEECPQH IRFVVAEARN
     FWPEFIAPDV SKLGECEFAL ISEMNSQLIV HHPYRTLSEL QPELSLTSDE VALAWSVIND
     HYLTDLPLLY PPHVIAVMAI IVAVVFKPSQ TSFHGTAAPL AGAMRDGGMN ILAALGDKNG
     AGPPPRIQKL VGWLAESEVD IRAVIECTQE LVSLYEIWEN YSEKHCKELL GRMVKSKNLD
     K