ID   SSN8_CANGA              Reviewed;         339 AA.
AC   Q6FJE8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN   Name=SSN8; OrderedLocusNames=CAGL0M06875g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR380959; CAG62622.1; -; Genomic_DNA.
DR   RefSeq; XP_449646.1; XM_449646.1.
DR   AlphaFoldDB; Q6FJE8; -.
DR   SMR; Q6FJE8; -.
DR   STRING; 5478.XP_449646.1; -.
DR   EnsemblFungi; CAG62622; CAG62622; CAGL0M06875g.
DR   GeneID; 2891695; -.
DR   KEGG; cgr:CAGL0M06875g; -.
DR   CGD; CAL0136591; CAGL0M06875g.
DR   VEuPathDB; FungiDB:CAGL0M06875g; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_2_1_1; -.
DR   InParanoid; Q6FJE8; -.
DR   OMA; MSGSYWT; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:1990508; C:CKM complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:EnsemblFungi.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0000411; P:positive regulation of transcription by galactose; IEA:EnsemblFungi.
DR   GO; GO:0010673; P:positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:EnsemblFungi.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT                   /id="PRO_0000314271"
FT   DOMAIN          93..194
FT                   /note="Cyclin N-terminal"
FT   REGION          48..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  39489 MW;  E87764C7319927E3 CRC64;
     MSGSYWTSMQ RQKWQHTKPS LARERQRLWV MECQLFPQGL NIIVDSKPNS ADSSNGNAAN
     NGGGNGRSQL VATTKNIPIT HRDLHYDKDY NLRIYCYFLI MKLGRRLNIR QYALATAHIY
     LSRFLLKASV REVNLYLLVT TCVYLACKVE ECPQYIRTLV SEARSLWPEF IPPDPTKVTE
     FEFYLIEELQ CYLIVHHPYK SMEQIVEALK EEPFKLTFTS DELQNCWSLI NDSFINDVHL
     TYAPHIIAMA CLFITVSIQG SNTKELSLTS AVTETLTSQS SLTPQQQTFF RFLAESHVDL
     EEVMDTIQQQ IILYDHWDRY HEPWIKYLLH TLYLRPLSA