ID   SSN8_CHAGB              Reviewed;         364 AA.
AC   Q2GVK1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN   Name=SSN8; ORFNames=CHGG_08003;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAQ86750.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH408033; EAQ86750.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001225659.1; XM_001225658.1.
DR   AlphaFoldDB; Q2GVK1; -.
DR   SMR; Q2GVK1; -.
DR   STRING; 38033.XP_001225659.1; -.
DR   EnsemblFungi; EAQ86750; EAQ86750; CHGG_08003.
DR   GeneID; 4393358; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_2_0_1; -.
DR   InParanoid; Q2GVK1; -.
DR   OrthoDB; 1079428at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..364
FT                   /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT                   /id="PRO_0000314272"
FT   DOMAIN          53..143
FT                   /note="Cyclin N-terminal"
FT   REGION          268..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  39849 MW;  8E2B2D8C846C8B1E CRC64;
     MAANYWESTQ RKHWQFTKQD LAAIRQRLDD EDPGLVQMFP LPQLRHLNIY FNQQINRLSK
     RIGLRQQVMA TAQVYLKRFY TRIAIRQTNP YLVLTTVLYL ACKMEECPQH IRMMTQEARS
     LWPSDLHGHD PARVGECEFS LISEMHSNLI VHQPYRSLLG VQDEFGLTQD EMSLAWTVIN
     DHYMTDLPLL HPPHVVALTA VLLALVLRPS ANTPAAGGAG GNAGAAAAAA AAGAGGVAMA
     ATALAQAQAQ VQARAAAIAA AGAGGGTPGF GSQGSQQQAG FSQGNSQGSL QGDSAAAEPK
     KVTDPRLAKV QRFAAWLADS NIDIEAMVDC TQELISFYEC HEQYNDKHTK EQISRFIKAR
     NLDK