ID   SSN8_DEBHA              Reviewed;         345 AA.
AC   Q6BYF8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN   Name=SSN8; OrderedLocusNames=DEHA2A09878g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR382133; CAG84722.2; -; Genomic_DNA.
DR   RefSeq; XP_456761.2; XM_456761.1.
DR   AlphaFoldDB; Q6BYF8; -.
DR   SMR; Q6BYF8; -.
DR   STRING; 4959.XP_456761.2; -.
DR   EnsemblFungi; CAG84722; CAG84722; DEHA2A09878g.
DR   GeneID; 2899553; -.
DR   KEGG; dha:DEHA2A09878g; -.
DR   VEuPathDB; FungiDB:DEHA2A09878g; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_2_1_1; -.
DR   InParanoid; Q6BYF8; -.
DR   OMA; WNRYNEQ; -.
DR   OrthoDB; 1079428at2759; -.
DR   Proteomes; UP000000599; Chromosome A.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   3: Inferred from homology;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..345
FT                   /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT                   /id="PRO_0000314274"
FT   DOMAIN          23..147
FT                   /note="Cyclin N-terminal"
SQ   SEQUENCE   345 AA;  39838 MW;  F5A3C2648A0336C3 CRC64;
     MSADFWSSSQ RNRWQLTRHS LLESRRKLLL LEKKMIQNGF IKDYPNVEYD ANTRIYLHNL
     LIKLGRRLNV RQIALATAEI YMSRFLIKVS LKEINVYLLV TTCLYAACKI EECPQHIRLI
     TSEARNLWPE YIPQDVTKLA EFEFYLIEEM DSFLVLHHPY RSLLQIRDYL NENFALYGFS
     LSDDELQNSW SLINDSYITD LHLLLPPHII AIATIYITIV LKKNISSLRL GANSMSNDTV
     GMDPHTKPNS NSIHAEDLMA LATGGSAIND IGNPSSGTNG FHDIELDENT IKINKFMTFL
     DHSHVNLNEV VEAIQDIITL YAIWNRYNEM SVKKVLQDML LNRSV