SSN8_GIBMO
ID SSN8_GIBMO Reviewed; 319 AA.
AC Q9C1M4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN Name=SSN8; Synonyms=FCC1;
OS Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium
OS verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=117187;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=11282612; DOI=10.1128/aem.67.4.1607-1612.2001;
RA Shim W.B., Woloshuk C.P.;
RT "Regulation of fumonisin B(1) biosynthesis and conidiation in Fusarium
RT verticillioides by a cyclin-like (C-type) gene, FCC1.";
RL Appl. Environ. Microbiol. 67:1607-1612(2001).
RN [2]
RP INTERACTION WITH SSN3.
RX PubMed=16504555; DOI=10.1016/j.fgb.2005.09.006;
RA Bluhm B.H., Woloshuk C.P.;
RT "Fck1, a C-type cyclin-dependent kinase, interacts with Fcc1 to regulate
RT development and secondary metabolism in Fusarium verticillioides.";
RL Fungal Genet. Biol. 43:146-154(2006).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II (By similarity). May play a role in signal
CC transduction pathways regulating secondary metabolism and fungal
CC development (conidiation). {ECO:0000250, ECO:0000269|PubMed:11282612}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex (By similarity). Interacts with SSN3/FCK1.
CC {ECO:0000250, ECO:0000269|PubMed:16504555}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; AF294431; AAK30047.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9C1M4; -.
DR SMR; Q9C1M4; -.
DR PRIDE; Q9C1M4; -.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Activator; Cyclin; Nucleus; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..319
FT /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT /id="PRO_0000314276"
FT DOMAIN 53..142
FT /note="Cyclin N-terminal"
FT REGION 237..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 36714 MW; 8CC5ADAFA160F5D2 CRC64;
MSANYWHSTQ CRFWSFTKEQ LVTMRQKLEE DNAELVRMFP LPQQRRLYIY FNQQLIRLAK
RLTIRQQSMA TAQVYMKRFY SKVEIRRTNP YLVIATAIYL ACKIEESPQH IRLIVTEARQ
MWGDLVAIDT SKLGECEFFM ISEMRSQLIV FQPYRTITAL RNELSLVDDE VQLARSVIND
HFMTDLPLLY PPHIIAMVAI LLALVLRPNN SGPGQSTSGA AAAAGLAAAQ QALMRAQGQQ
AQGGMPEPAA AEPKEKRQQD RVSRVQKFAK WLVDSNVEIA SMVDATQEII SFYECYEHYN
DKLTREQINR FVKARGLDK
