SSN8_PICST
ID SSN8_PICST Reviewed; 346 AA.
AC A3LPX1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
GN Name=SSN8; ORFNames=PICST_54418;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; CP000496; ABN64572.2; -; Genomic_DNA.
DR RefSeq; XP_001382601.2; XM_001382564.1.
DR AlphaFoldDB; A3LPX1; -.
DR SMR; A3LPX1; -.
DR STRING; 4924.XP_001382601.2; -.
DR PRIDE; A3LPX1; -.
DR EnsemblFungi; ABN64572; ABN64572; PICST_54418.
DR GeneID; 4836885; -.
DR KEGG; pic:PICST_54418; -.
DR eggNOG; KOG0794; Eukaryota.
DR HOGENOM; CLU_034754_2_1_1; -.
DR InParanoid; A3LPX1; -.
DR OMA; WNRYNEQ; -.
DR OrthoDB; 1079428at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..346
FT /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT /id="PRO_0000314280"
FT DOMAIN 59..158
FT /note="Cyclin N-terminal"
SQ SEQUENCE 346 AA; 40545 MW; 8052D186D62C7C0B CRC64;
MSADFWCSSQ RNKWQLSRQS LLEARRKVLL LERKMIQNGL IKDYPNIHYD FNMRIYLHNL
LIKLGRRLNI RQVALATAEI YLNRFLTRVS LKEINVYLLV TTCLYVACKI EECPQHIRLI
ISEARNLWPE YIPHDVTKLA EFEFYLIEEM DSYLFLHHPY KSLIQIRDFL NENSAVFGFT
LTDDELQNAW SLVNDSYITD LHLLLPPHII AVASIYITIV LKKNLSAIRV NSSAVNSNGG
PNSMMFNRNP DQNSMHIDDL MILANPSTPG SDLVNNLERT NFHDMKLDEE TIKINKFMNF
LDHSHINLDE VVEAMQDMIN IYVQWNRYNE QGVKKALQVM LLNRQL
