SSP2_PLAYO
ID SSP2_PLAYO Reviewed; 827 AA.
AC Q01443; Q7RK51;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Sporozoite surface protein 2;
DE Flags: Precursor;
GN Name=SSP2; ORFNames=PY03052;
OS Plasmodium yoelii yoelii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=73239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1501644; DOI=10.1016/0166-6851(92)90005-5;
RA Rogers W.O., Rogers M.D., Hedstrom R.C., Hoffman S.L.;
RT "Characterization of the gene encoding sporozoite surface protein 2, a
RT protective Plasmodium yoelii sporozoite antigen.";
RL Mol. Biochem. Parasitol. 53:45-51(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17XNL;
RX PubMed=12368865; DOI=10.1038/nature01099;
RA Carlton J.M., Angiuoli S.V., Suh B.B., Kooij T.W., Pertea M., Silva J.C.,
RA Ermolaeva M.D., Allen J.E., Selengut J.D., Koo H.L., Peterson J.D., Pop M.,
RA Kosack D.S., Shumway M.F., Bidwell S.L., Shallom S.J., van Aken S.E.,
RA Riedmuller S.B., Feldblyum T.V., Cho J.K., Quackenbush J., Sedegah M.,
RA Shoaibi A., Cummings L.M., Florens L., Yates J.R. III, Raine J.D.,
RA Sinden R.E., Harris M.A., Cunningham D.A., Preiser P.R., Bergman L.W.,
RA Vaidya A.B., van Lin L.H., Janse C.J., Waters A.P., Smith H.O., White O.R.,
RA Salzberg S.L., Venter J.C., Fraser C.M., Hoffman S.L., Gardner M.J.,
RA Carucci D.J.;
RT "Genome sequence and comparative analysis of the model rodent malaria
RT parasite Plasmodium yoelii yoelii.";
RL Nature 419:512-519(2002).
RN [3]
RP PROTEIN SEQUENCE OF 562-567.
RX PubMed=2094580;
RA Hedstrom R.C., Campbell J.R., Leef M.L., Charoenvit Y., Carter M.,
RA Sedegah M., Beaudoin R.L., Hoffman S.L.;
RT "A malaria sporozoite surface antigen distinct from the circumsporozoite
RT protein.";
RL Bull. World Health Organ. 68:152-157(1990).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
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DR EMBL; M84732; AAA29768.1; -; Genomic_DNA.
DR EMBL; AABL01000864; EAA22580.1; -; Genomic_DNA.
DR PIR; A45559; A45559.
DR AlphaFoldDB; Q01443; -.
DR SMR; Q01443; -.
DR STRING; 73239.Q01443; -.
DR EnsemblProtists; EAA22580; EAA22580; EAA22580.
DR InParanoid; Q01443; -.
DR OMA; PEDNDWN; -.
DR Proteomes; UP000008553; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.20.100.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF82895; SSF82895; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Disulfide bond; Malaria;
KW Membrane; Reference proteome; Repeat; Signal; Sporozoite; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..827
FT /note="Sporozoite surface protein 2"
FT /id="PRO_0000024627"
FT TRANSMEM 764..787
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 43..228
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 235..281
FT /note="TSP type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT REPEAT 603..613
FT /note="1"
FT REPEAT 614..624
FT /note="2"
FT REGION 278..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..392
FT /note="29 X 3 AA tandem repeats"
FT REGION 402..514
FT /note="20 tandem tetra-/hexapeptide repeats"
FT REGION 603..624
FT /note="2 X 11 AA tandem repeats"
FT COMPBIAS 280..391
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..586
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 238..267
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 247..275
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT DISULFID 251..280
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210"
FT CONFLICT 390..391
FT /note="PN -> H (in Ref. 1; AAA29768)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="K -> R (in Ref. 1; AAA29768)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 827 AA; 91299 MW; 8AD73981E6BBB4A3 CRC64;
MKLLGNSKYI FVVLLLCISV FLNGQETLDE IKYSEEVCTE QIDIHILLDG SGSIGYSNWK
AHVIPMLNTL VDNLNISNDE INVSLTLFST NSRELIKLKG YGSTSKDSLR FILAHLQNNY
SPNGNTNLTS ALLVVDTLIN ERMYRPDAIQ LAIILTDGIP NDLPRSTAVV HQLKRKHVNV
AIIGVGAGVN NEYNRILVGC DRYAPCPYYS SGSWNEAQNM IKPFLTKVCQ EVERIAHCGK
WEEWSECSTT CDEGRKIRRR QILHPGCVSE MTTPCKVRDC PQIPIPPVIP NKIPEKPSNP
EEPVNPNDPN DPNNPNNPNN PNNPNNPNNP NNPNNPNNPN NPNNPNNPNN PNNPNNPNNP
NNPNNPNNPN NPNNPNNPNN PNDPSNPNNP NPKKRNPKRR NPNKPKPNKP NPNKPNPNEP
SNPNKPNPNE PSNPNKPNPN EPSNPNKPNP NEPSNPNKPN PNEPLNPNEP SNPNEPSNPN
APSNPNEPSN PNEPSNPNEP SNPNEPSNPN EPSNPKKPSN PNEPSNPNEP LNPNEPSNPN
EPSNPNEPSN PEEPSNPKEP SNPNEPSNPE EPNPEEPSNP KEPSNPEEPI NPEELNPKEP
SNPEESNPKE PINPEESNPK EPINPEDNEN PLIIQDEPIE PRNDSNVIPI LPIIPQKGNN
IPSNLPENPS DSEVEYPRPN DNGENSNNTM KSKKNIPNEP IPSPGDNPYK GHEERIPKPH
RSNDDYVYDN NVNKNNKDEP EIPNNEYEED KNKNQSKSNN GYKIAGGIIG GLAILGCAGV
GYNFIAGSSA AGLAGAEPAP FEDVIPDDDK DIVENEQFKL PEDNDWN
