ID   SSPA_COXBU              Reviewed;         209 AA.
AC   Q83AY0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Stringent starvation protein A homolog;
GN   Name=sspA; OrderedLocusNames=CBU_1747;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA   Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA   Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA   Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA   Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Nine Mile Crazy / RSA 514;
RX   PubMed=17088354; DOI=10.1128/iai.00883-06;
RA   Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J.,
RA   Samuel J.E., Heinzen R.A.;
RT   "Proteome and antigen profiling of Coxiella burnetii developmental forms.";
RL   Infect. Immun. 75:290-298(2007).
CC   -!- FUNCTION: Forms an equimolar complex with the RNA polymerase holoenzyme
CC       (RNAP) but not with the core enzyme. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: More than twofold more abundant in the large cell
CC       variant (LCV) stage than in the small cell variant (SCV) stage (at
CC       protein level). LCVs are more metabolically active than SCVs.
CC       {ECO:0000269|PubMed:17088354}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. HSP26 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO91241.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016828; AAO91241.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_820727.2; NC_002971.3.
DR   AlphaFoldDB; Q83AY0; -.
DR   SMR; Q83AY0; -.
DR   STRING; 227377.CBU_1747; -.
DR   EnsemblBacteria; AAO91241; AAO91241; CBU_1747.
DR   GeneID; 1209658; -.
DR   KEGG; cbu:CBU_1747; -.
DR   PATRIC; fig|227377.7.peg.1736; -.
DR   eggNOG; COG0625; Bacteria.
DR   HOGENOM; CLU_011226_9_3_6; -.
DR   OMA; ADHYSHR; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   CDD; cd03059; GST_N_SspA; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR034341; SspA_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..209
FT                   /note="Stringent starvation protein A homolog"
FT                   /id="PRO_0000322128"
FT   DOMAIN          5..83
FT                   /note="GST N-terminal"
FT   DOMAIN          88..203
FT                   /note="GST C-terminal"
SQ   SEQUENCE   209 AA;  24415 MW;  90B687E56996D708 CRC64;
     MLKRSIMTLY SGPLDIYSHQ VRIVLAEKGV TVDIHNVDAN HPSEDLIELN PYATLPTLVD
     RDLVLFESRV IMEYLDERFP HPPLLPVYPV ARSRCRLLMY RIERNFYHSM KIIEEGTPKQ
     AETEREFLTK ELIELDPVFG EKTYFMNDDF TLVDCVMAPL LWRLPHLGVH VPPRAAKSMY
     KYKKLIFERE SFKASLSESE SELREVDGI