ID   SSPA_ECO57              Reviewed;         212 AA.
AC   P0ACA5; P05838;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Stringent starvation protein A;
GN   Name=sspA; OrderedLocusNames=Z4587, ECs4102;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Forms an equimolar complex with the RNA polymerase holoenzyme
CC       (RNAP) but not with the core enzyme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GST superfamily. HSP26 family.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG58357.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB37525.1; -; Genomic_DNA.
DR   PIR; A85987; A85987.
DR   PIR; F91141; F91141.
DR   RefSeq; NP_312129.1; NC_002695.1.
DR   RefSeq; WP_000257293.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACA5; -.
DR   SMR; P0ACA5; -.
DR   STRING; 155864.EDL933_4451; -.
DR   PRIDE; P0ACA5; -.
DR   EnsemblBacteria; AAG58357; AAG58357; Z4587.
DR   EnsemblBacteria; BAB37525; BAB37525; ECs_4102.
DR   GeneID; 67415939; -.
DR   GeneID; 916049; -.
DR   KEGG; ece:Z4587; -.
DR   KEGG; ecs:ECs_4102; -.
DR   PATRIC; fig|386585.9.peg.4282; -.
DR   eggNOG; COG0625; Bacteria.
DR   HOGENOM; CLU_011226_9_3_6; -.
DR   OMA; ADHYSHR; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR   CDD; cd03186; GST_C_SspA; 1.
DR   CDD; cd03059; GST_N_SspA; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR034342; SspA_C.
DR   InterPro; IPR034341; SspA_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..212
FT                   /note="Stringent starvation protein A"
FT                   /id="PRO_0000185877"
FT   DOMAIN          9..87
FT                   /note="GST N-terminal"
FT   DOMAIN          92..209
FT                   /note="GST C-terminal"
SQ   SEQUENCE   212 AA;  24305 MW;  A0FFA98F7131B34F CRC64;
     MAVAANKRSV MTLFSGPTDI YSHQVRIVLA EKGVSFEIEH VEKDNPPQDL IDLNPNQSVP
     TLVDRELTLW ESRIIMEYLD ERFPHPPLMP VYPVARGESR LYMHRIEKDW YTLMNTIING
     SASEADAARK QLREELLAIA PVFGQKPYFL SDEFSLVDCY LAPLLWRLPQ LGIEFSGPGA
     KELKGYMTRV FERDSFLASL TEAEREMRLG RS