SSPA_HAEIN
ID SSPA_HAEIN Reviewed; 212 AA.
AC P45207;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Stringent starvation protein A homolog;
GN Name=sspA; OrderedLocusNames=HI_1441;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 8-212.
RG New York structural genomix research consortium (NYSGXRC);
RT "Structure of stringent starvation protein a homolog from Haemophilus
RT influenzae.";
RL Submitted (MAR-2010) to the PDB data bank.
CC -!- FUNCTION: Forms an equimolar complex with the RNA polymerase holoenzyme
CC (RNAP) but not with the core enzyme. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GST superfamily. HSP26 family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC23090.1; -; Genomic_DNA.
DR PIR; E64123; E64123.
DR RefSeq; NP_439593.1; NC_000907.1.
DR RefSeq; WP_005650452.1; NC_000907.1.
DR PDB; 3LYK; X-ray; 2.10 A; A/B=12-212.
DR PDBsum; 3LYK; -.
DR AlphaFoldDB; P45207; -.
DR SMR; P45207; -.
DR STRING; 71421.HI_1441; -.
DR DNASU; 950832; -.
DR EnsemblBacteria; AAC23090; AAC23090; HI_1441.
DR KEGG; hin:HI_1441; -.
DR PATRIC; fig|71421.8.peg.1503; -.
DR eggNOG; COG0625; Bacteria.
DR HOGENOM; CLU_011226_9_3_6; -.
DR OMA; ADHYSHR; -.
DR PhylomeDB; P45207; -.
DR BioCyc; HINF71421:G1GJ1-1467-MON; -.
DR EvolutionaryTrace; P45207; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0006749; P:glutathione metabolic process; IEA:InterPro.
DR CDD; cd03186; GST_C_SspA; 1.
DR CDD; cd03059; GST_N_SspA; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR034342; SspA_C.
DR InterPro; IPR034341; SspA_N.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..212
FT /note="Stringent starvation protein A homolog"
FT /id="PRO_0000185880"
FT DOMAIN 9..87
FT /note="GST N-terminal"
FT DOMAIN 92..212
FT /note="GST C-terminal"
FT STRAND 12..15
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 20..32
FT /evidence="ECO:0007829|PDB:3LYK"
FT STRAND 37..40
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 48..53
FT /evidence="ECO:0007829|PDB:3LYK"
FT STRAND 61..64
FT /evidence="ECO:0007829|PDB:3LYK"
FT STRAND 67..71
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 72..82
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 93..109
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 111..119
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 122..138
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 140..145
FT /evidence="ECO:0007829|PDB:3LYK"
FT STRAND 146..148
FT /evidence="ECO:0007829|PDB:3LYK"
FT STRAND 151..153
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 156..169
FT /evidence="ECO:0007829|PDB:3LYK"
FT TURN 170..172
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 180..191
FT /evidence="ECO:0007829|PDB:3LYK"
FT HELIX 194..199
FT /evidence="ECO:0007829|PDB:3LYK"
SQ SEQUENCE 212 AA; 24290 MW; 8BC4DC08CFAFF115 CRC64;
MSSASSKRSV MTLFSNKDDI YCHQVKIVLA EKGVLYENAE VDLQALPEDL MELNPYGTVP
TLVDRDLVLF NSRIIMEYLD ERFPHPPLMQ VYPVSRAKDR LLMLRIEQDW YPTLAKAENG
TEKEKTSALK QLKEELLGIA PIFQQMPYFM NEEFGLVDCY VAPLLWKLKH LGVEFTGTGS
KAIKAYMERV FTRDSFLQSV GEAAPKNLMD DK
